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. 2016 May 18:8:211-9.
doi: 10.1016/j.dib.2016.04.069. eCollection 2016 Sep.

Data from acellular human heart matrix

Pedro L Sánchez  1 , M Eugenia Fernández-Santos  2 , M Angeles Espinosa  3 , M Angeles González-Nicolas  2 , Judith R Acebes  2 , Salvatore Costanza  4 , Isabel Moscoso  5 , Hugo Rodríguez  6 , Julio García  7 , Jesús Romero  8 , Stefan M Kren  9 , Javier Bermejo  10 , Raquel Yotti  10 , Candelas Pérez Del Villar  10 , Ricardo Sanz-Ruiz  10 , Jaime Elizaga  10 , Doris A Taylor  11 , Francisco Fernández-Avilés  3
Affiliations

Data from acellular human heart matrix

Pedro L Sánchez et al. Data Brief. .

Abstract

Perfusion decellularization of cadaveric hearts removes cells and generates a cell-free extracellular matrix scaffold containing acellular vascular conduits, which are theoretically sufficient to perfuse and support tissue-engineered heart constructs. This article contains additional data of our experience decellularizing and testing structural integrity and composition of a large series of human hearts, "Acellular human heart matrix: a critical step toward whole heat grafts" (Sanchez et al., 2015) [1]. Here we provide the information about the heart decellularization technique, the valve competence evaluation of the decellularized scaffolds, the integrity evaluation of epicardial and myocardial coronary circulation, the pressure volume measurements, the primers used to assess cardiac muscle gene expression and, the characteristics of donors, donor hearts, scaffolds and perfusion decellularization process.

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Figures

Fig. 1.
Fig. 1
Heart decellularization technique.
Fig. 2.
Fig. 2
Valve competence evaluation during systole and diastole using echocardiography from the epicardium.
Fig. 3.
Fig. 3
Angiographic coronary vascular study.
Fig. 4.
Fig. 4
Pressure–volume measurement to assess global chamber mechanical passive properties.
See this image and copyright information in PMC

References

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