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Case Reports
. 2016 Apr 26:16:47-50.
doi: 10.1016/j.gore.2016.04.005. eCollection 2016 Apr.

Malignant melanoma arising in a mature teratoma: A case report with review of the recent literature

Lorna A Brudie  1 , Faizan Khan  1 , Michael J Radi  2 , Melissa M Yates  3 , Sarfraz Ahmad  1
Affiliations
Case Reports

Malignant melanoma arising in a mature teratoma: A case report with review of the recent literature

Lorna A Brudie et al. Gynecol Oncol Rep. .

Abstract

Mature cystic teratomas constitute 10-20% of all ovarian neoplasms. Malignant transformation is very rare occurring in only 0.1-2% of mature teratoma cases. Malignant melanoma is among the least common transformations. Herein, we describe a case of young woman initially undergoing evaluation for infertility who was found to have malignant melanoma arising in a mature dermoid cyst. She subsequently underwent unilateral salpingo-oophorectomy with staging procedure with benign pathology. There was no need for adjuvant therapy and the patient is without disease to date (nearly 10-months in follow-up now). We reviewed the existing literature and this is one of only a few cases documented in the last decade.

Keywords: Dermoid; Literature review; Malignant melanoma; Mature teratoma; Prognosis; Treatments.

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Figures

Fig. 1
Fig. 1
Mature squamous epithelium in the ovarian teratoma contains numerous junctional nests of atypical melanocytes. Arrows mark an area shown at higher power (H&E stain, 4 ×).
Fig. 2
Fig. 2
Nests of melanoma in situ are present at the epithelial-stromal junction and invasive melanoma is present in the stroma accompanied by a prominent lymphocytic reaction (H&E, 20 ×).
Fig. 3
Fig. 3
Invasive melanoma (H&E, 40 ×).
See this image and copyright information in PMC

References

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