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. 2016 Oct;22(10):1824-6.
doi: 10.3201/eid2210.160706. Epub 2016 Oct 15.

Persistence of Antibodies against Middle East Respiratory Syndrome Coronavirus

Daniel C Payne, Ibrahim Iblan, Brian Rha, Sultan Alqasrawi, Aktham Haddadin, Mohannad Al Nsour, Tarek Alsanouri, Sami Sheikh Ali, Jennifer Harcourt, Congrong Miao, Azaibi Tamin, Susan I Gerber, Lia M Haynes, Mohammad Mousa Al Abdallat

Persistence of Antibodies against Middle East Respiratory Syndrome Coronavirus

Daniel C Payne et al. Emerg Infect Dis. 2016 Oct.

Abstract

To determine how long antibodies against Middle East respiratory syndrome coronavirus persist, we measured long-term antibody responses among persons serologically positive or indeterminate after a 2012 outbreak in Jordan. Antibodies, including neutralizing antibodies, were detectable in 6 (86%) of 7 persons for at least 34 months after the outbreak.

Keywords: Jordan; MERS-CoV; Middle East respiratory syndrome; antibody; novel coronavirus; respiratory infections; serology; severe acute respiratory illness; viruses.

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Figures

Figure
Figure
Neutralizing antibody titers against Middle East respiratory syndrome coronavirus (Hu/Jordan-N3/2012 strain) among 7 surviving case-patients at 13 and 34 months after the 2012 outbreak in Jordan. Patient numbers match those in the Table.
See this image and copyright information in PMC

References

    1. Al-Abdallat MM, Payne DC, Alqaswari S. Rha B, Tohme RA, Abedi GRet al. Hospital associated outbreak of Middle Eastern respiratory syndrome coronavirus: a serologic, clinical, and epidemiologic description. Clin Infect Dis. 2014;59:1225–33. 10.1093/cid/ciu359 - DOI - PMC - PubMed
    1. Mo H, Zeng G, Ren X. Li H, Ke C, Tan Y, et al. Longitudinal profile of antibodies against SARS-coronavirus in SARS patients and their clinical significance. Respirology. 2006;11:49–53. 10.1111/j.1440-1843.2006.00783.x - DOI - PMC - PubMed
    1. Alshukairi AN, Khalid I, Ahmed WA. Dada AM, Bayumi DT, Malic LS, et al. Antibody response and disease severity in healthcare worker MERS survivors. Emerg Infect Dis. 2016;22. 10.3201/eid2206.160010 - DOI - PMC - PubMed
    1. Zumla A, Hui DS, Perlman S. Middle East respiratory syndrome. Lancet. 2015;386:995–1007. 10.1016/S0140-6736(15)60454-8 - DOI - PMC - PubMed
    1. Korea Centers for Disease Control and Prevention. Middle East respiratory syndrome coronavirus outbreak in the Republic of Korea, 2015. Osong Public Health Res Perspect. 2015;6:269–78. 10.1016/j.phrp.2015.08.006 - DOI - PMC - PubMed

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