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Comment
. 2016 Jun 21;44(6):1243-5.
doi: 10.1016/j.immuni.2016.06.004.

InterFeriNg with Acetγlation: Stress-Levels of Acetate Improve Memory T Cell Function

Caroline A Lewis  1 , Matthew G Vander Heiden  2
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InterFeriNg with Acetγlation: Stress-Levels of Acetate Improve Memory T Cell Function

Caroline A Lewis et al. Immunity. .
Free article

Abstract

Catabolic stress can lead to changes in circulating acetate levels. In this issue of Immunity, Balmer et al. (2016) report that serum acetate increases in response to acute infection and describe a mechanism by which this results in acetylation of the glycolytic enzyme GAPDH and improves the recall function of memory CD8(+) T cells.

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