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Comment
. 2016 Jun 21;44(6):1248-50.
doi: 10.1016/j.immuni.2016.06.010.

Driving CARs into Sweet Roads: Targeting Glycosylated Antigens in Cancer

Ada G Blidner  1 , Karina V Mariño  2 , Gabriel A Rabinovich  3
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Driving CARs into Sweet Roads: Targeting Glycosylated Antigens in Cancer

Ada G Blidner et al. Immunity. .
Free article

Abstract

Engineering T cells with chimeric antigen receptors (CARs) has demonstrated remarkable success in eradicating hematological malignancies. In this issue of Immunity, June and colleagues demonstrate the broad antitumor efficacy of a newly-designed CAR targeting the O-linked hypoglycosylated epitopes Tn and sialyl-Tn on cancer-associated MUC-1.

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