Broadly Neutralizing Antibodies: Magic Bullets against HIV?

Boris Julg¹, Galit Alter²

Affiliations

¹ Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
² Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. Electronic address: galter@partners.org.

PMID: 27332729
DOI: 10.1016/j.immuni.2016.06.012

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Broadly Neutralizing Antibodies: Magic Bullets against HIV?

Boris Julg et al. Immunity. 2016.

Free article

. 2016 Jun 21;44(6):1253-4.

doi: 10.1016/j.immuni.2016.06.012.

Authors

Boris Julg¹, Galit Alter²

Affiliations

¹ Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
² Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA. Electronic address: galter@partners.org.

PMID: 27332729
DOI: 10.1016/j.immuni.2016.06.012

Abstract

Broadly neutralizing antibodies (bNAbs) offer new avenues for HIV prevention and cure strategies. Three recent papers, published in Science and Nature, highlight the broad applicability of bNAbs in HIV cure and prevention and in boosting immunity against HIV.

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A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges.
Gautam R, Nishimura Y, Pegu A, Nason MC, Klein F, Gazumyan A, Golijanin J, Buckler-White A, Sadjadpour R, Wang K, Mankoff Z, Schmidt SD, Lifson JD, Mascola JR, Nussenzweig MC, Martin MA. Gautam R, et al. Nature. 2016 May 5;533(7601):105-109. doi: 10.1038/nature17677. Epub 2016 Apr 27. Nature. 2016. PMID: 27120156 Free PMC article.
HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1.
Schoofs T, Klein F, Braunschweig M, Kreider EF, Feldmann A, Nogueira L, Oliveira T, Lorenzi JC, Parrish EH, Learn GH, West AP Jr, Bjorkman PJ, Schlesinger SJ, Seaman MS, Czartoski J, McElrath MJ, Pfeifer N, Hahn BH, Caskey M, Nussenzweig MC. Schoofs T, et al. Science. 2016 May 20;352(6288):997-1001. doi: 10.1126/science.aaf0972. Epub 2016 May 5. Science. 2016. PMID: 27199429 Free PMC article. Clinical Trial.
Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo.
Lu CL, Murakowski DK, Bournazos S, Schoofs T, Sarkar D, Halper-Stromberg A, Horwitz JA, Nogueira L, Golijanin J, Gazumyan A, Ravetch JV, Caskey M, Chakraborty AK, Nussenzweig MC. Lu CL, et al. Science. 2016 May 20;352(6288):1001-4. doi: 10.1126/science.aaf1279. Epub 2016 May 5. Science. 2016. PMID: 27199430 Free PMC article.

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Broadly Neutralizing Antibodies: Magic Bullets against HIV?

Affiliations

Broadly Neutralizing Antibodies: Magic Bullets against HIV?

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Grants and funding

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