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. 2017 Jan;17(1):140-150.
doi: 10.1111/ajt.13929. Epub 2016 Jul 22.

Banff Histopathological Consensus Criteria for Preimplantation Kidney Biopsies

H Liapis  1   2 , J P Gaut  1 , C Klein  3 , S Bagnasco  4 , E Kraus  4 , A B Farris 3rd  5 , E Honsova  6 , A Perkowska-Ptasinska  7 , D David  8 , J Goldberg  9 , M Smith  10 , M Mengel  11 , M Haas  12 , S Seshan  13 , K L Pegas  14 , T Horwedel  15 , Y Paliwa  16 , X Gao  16 , D Landsittel  16 , P Randhawa  16 ; Banff Working Group
Affiliations

Banff Histopathological Consensus Criteria for Preimplantation Kidney Biopsies

H Liapis et al. Am J Transplant. 2017 Jan.

Abstract

The Banff working group on preimplantation biopsy was established to develop consensus criteria (best practice guidelines) for the interpretation of preimplantation kidney biopsies. Digitally scanned slides were used (i) to evaluate interobserver variability of histopathologic findings, comparing frozen sections with formalin-fixed, paraffin-embedded tissue of wedge and needle core biopsies, and (ii) to correlate consensus histopathologic findings with graft outcome in a cohort of biopsies from international medical centers. Intraclass correlations (ICCs) and univariable and multivariable statistical analyses were performed. Good to fair reproducibility was observed in semiquantitative scores for percentage of glomerulosclerosis, arterial intimal fibrosis and interstitial fibrosis on frozen wedge biopsies. Evaluation of frozen wedge and core biopsies was comparable for number of glomeruli, but needle biopsies showed worse ICCs for glomerulosclerosis, interstitial fibrosis and tubular atrophy. A consensus evaluation form is provided to help standardize the reporting of histopathologic lesions in donor biopsies. It should be recognized that histologic parameters may not correlate with graft outcome in studies based on organs deemed to be acceptable after careful clinical assessment. Significant limitations remain in the assessment of implantation biopsies.

Keywords: biopsy; clinical research/practice; donors and donation: deceased; kidney (allograft) function/dysfunction; kidney failure/injury; pathology/histopathology.

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Figures

Figure 1
Figure 1
Example of whole‐slide imaging of a needle core implantation biopsy used for digital scoring.
Figure 2
Figure 2
Donor biopsy scoring sheet.
See this image and copyright information in PMC

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