[Advances in Liquid Biopsy and its Clinical Application in the Diagnosis and Treatment of Non-small Cell Lung Cancer]

doi:10.3779/j.issn.1009-3419.2016.06.19

Review

. 2016 Jun 20;19(6):394-8.

doi: 10.3779/j.issn.1009-3419.2016.06.19.

[Advances in Liquid Biopsy and its Clinical Application in the Diagnosis and Treatment of Non-small Cell Lung Cancer]

[Article in Chinese]

Difan Zheng¹, Haiquan Chen¹

Affiliations

PMID: 27335304
PMCID: PMC6015208
DOI: 10.3779/j.issn.1009-3419.2016.06.19

Review

[Advances in Liquid Biopsy and its Clinical Application in the Diagnosis and Treatment of Non-small Cell Lung Cancer]

[Article in Chinese]

Difan Zheng et al. Zhongguo Fei Ai Za Zhi. 2016.

. 2016 Jun 20;19(6):394-8.

doi: 10.3779/j.issn.1009-3419.2016.06.19.

Authors

Difan Zheng¹, Haiquan Chen¹

Affiliation

¹ Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

PMID: 27335304
PMCID: PMC6015208
DOI: 10.3779/j.issn.1009-3419.2016.06.19

Abstract
in English, Chinese

With the advances of technology, great progresses have been made in liquid biopsy in recent years. Liquid biopsy is currently playing a more and more important role in early diagnosis and treatment of cancer. Compared with traditional tissue biopsy, liquid biopsy is more popular in clinical practice due to its non-invasiveness, convenience and high repeatability. It has huge potential in the future. This review introduces circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) as the most important objects in liquid biopsy, mainly focusing on their history, biological characteristics, detection technologies, limitations and applications in non-small cell lung cancer.

随着近几年科学技术的进步，液体活检技术也有了长足的发展，并在肿瘤的早期诊断及后期治疗中扮演着越来越重要的角色。相比于传统的组织活检，液体活检以其独有的无创性、便捷性、高重复性等特点在临床上得到更多的青睐，在未来有着巨大的发展潜力。本文重点探讨了循环肿瘤细胞（circulating tumor cells, CTCs）和循环肿瘤DNA（circulating tumor DNA, ctDNA），作为液体活检最重要的两个检测对象，其历史、生物学特性，检测手段，局限性及其在非小细胞肺癌诊治中的应用。.

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References

1. Maskell NA, Gleeson FV, Davies RJ. Standard pleural biopsy versus CT-guided cutting-needle biopsy for diagnosis of malignant disease in pleural effusions: a randomised controlled trial. http://www.thelancet.com/journals/lancet/article/PIIS0140673603130796/ab... Lancet. 2003;61(9366):1326–1330. - PubMed
1. Veronesi U, Paganelli G, Viale G, et al. A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med. 2003;349(6):546–553. doi: 10.1056/NEJMoa012782. - DOI - PubMed
1. Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012;366(10):883–892. doi: 10.1056/NEJMoa1113205. - DOI - PMC - PubMed
1. Crowley E, Di Nicolantonio F, Loupakis F, et al. Liquid biopsy: monitoring cancer-genetics in the blood. Nat Rev Clin Oncol. 2013;10(8):472–484. doi: 10.1038/nrclinonc.2013.110. - DOI - PubMed
1. Gupta GP, Massague J. Cancer metastasis: building a framework. Cell. 2006;127(4):679–695. doi: 10.1016/j.cell.2006.11.001. - DOI - PubMed

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[1] Maskell NA, Gleeson FV, Davies RJ. Standard pleural biopsy versus CT-guided cutting-needle biopsy for diagnosis of malignant disease in pleural effusions: a randomised controlled trial. http://www.thelancet.com/journals/lancet/article/PIIS0140673603130796/ab... Lancet. 2003;61(9366):1326–1330. - PubMed

[2] Maskell NA, Gleeson FV, Davies RJ. Standard pleural biopsy versus CT-guided cutting-needle biopsy for diagnosis of malignant disease in pleural effusions: a randomised controlled trial. http://www.thelancet.com/journals/lancet/article/PIIS0140673603130796/ab... Lancet. 2003;61(9366):1326–1330. - PubMed

[3] Veronesi U, Paganelli G, Viale G, et al. A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med. 2003;349(6):546–553. doi: 10.1056/NEJMoa012782. - DOI - PubMed

[4] Veronesi U, Paganelli G, Viale G, et al. A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med. 2003;349(6):546–553. doi: 10.1056/NEJMoa012782. - DOI - PubMed

[5] Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012;366(10):883–892. doi: 10.1056/NEJMoa1113205. - DOI - PMC - PubMed

[6] Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012;366(10):883–892. doi: 10.1056/NEJMoa1113205. - DOI - PMC - PubMed

[7] Crowley E, Di Nicolantonio F, Loupakis F, et al. Liquid biopsy: monitoring cancer-genetics in the blood. Nat Rev Clin Oncol. 2013;10(8):472–484. doi: 10.1038/nrclinonc.2013.110. - DOI - PubMed

[8] Crowley E, Di Nicolantonio F, Loupakis F, et al. Liquid biopsy: monitoring cancer-genetics in the blood. Nat Rev Clin Oncol. 2013;10(8):472–484. doi: 10.1038/nrclinonc.2013.110. - DOI - PubMed

[9] Gupta GP, Massague J. Cancer metastasis: building a framework. Cell. 2006;127(4):679–695. doi: 10.1016/j.cell.2006.11.001. - DOI - PubMed

[10] Gupta GP, Massague J. Cancer metastasis: building a framework. Cell. 2006;127(4):679–695. doi: 10.1016/j.cell.2006.11.001. - DOI - PubMed

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[Advances in Liquid Biopsy and its Clinical Application in the Diagnosis and Treatment of Non-small Cell Lung Cancer]

Affiliation

[Advances in Liquid Biopsy and its Clinical Application in the Diagnosis and Treatment of Non-small Cell Lung Cancer]

Authors

Affiliation

Abstract
in English, Chinese

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References

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Abstract in English, Chinese

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Abstract
in English, Chinese