Comparative Study
doi: 10.1016/0024-3205(89)90566-3.
Prolactin stimulation of protein kinase C activity in rat aortic smooth muscle
Affiliations
- PMID: 2733552
- DOI: 10.1016/0024-3205(89)90566-3
Item in Clipboard
Comparative Study
Prolactin stimulation of protein kinase C activity in rat aortic smooth muscle
Life Sci.
1989.
Abstract
Prolactin (PRL) activated protein kinase C (PKC) in a dose dependent manner in rat aortic smooth muscle. Aortic strips incubated with sub-nanomolar concentrations of ovine PRL for 25 min. at 37 degrees C showed a significant stimulation of PKC activity in both cytosolic and particulate fractions. This activation could be blocked using either anti-PRL antibodies or 1-(5- isoquinolinesulfonyl)-2-methylpiperazine (H-7), a PKC inhibitor. The results further support the role of PKC in the signal transduction pathway for PRL action and suggest that this activation may be involved in vascular smooth muscle function.
Similar articles
-
Prolactin induces proliferation of vascular smooth muscle cells through a protein kinase C-dependent mechanism.J Cell Physiol. 1991 Jul;148(1):133-8. doi: 10.1002/jcp.1041480116. J Cell Physiol. 1991. PMID: 1860893
-
Endothelin inhibits the atrial natriuretic factor stimulated cGMP production by activating the protein kinase C in rat aortic smooth muscle cells.Biochem Biophys Res Commun. 1992 Jan 15;182(1):395-402. doi: 10.1016/s0006-291x(05)80158-5. Biochem Biophys Res Commun. 1992. PMID: 1310017
-
Studies on the possible role of protein kinase C in the prolactin regulation of cell replication in Nb2 node lymphoma cells.Proc Soc Exp Biol Med. 1989 Nov;192(2):140-4. doi: 10.3181/00379727-192-42968. Proc Soc Exp Biol Med. 1989. PMID: 2813443
-
Prolactin and known modulators of rat splenocytes activate nuclear protein kinase C.Eur J Pharmacol. 1990 Mar 13;188(2-3):139-52. doi: 10.1016/0922-4106(90)90049-4. Eur J Pharmacol. 1990. PMID: 2318255
-
Characterization of glucose-induced in situ protein kinase C activity in cultured vascular smooth muscle cells.Diabetes. 1992 Nov;41(11):1464-72. doi: 10.2337/diab.41.11.1464. Diabetes. 1992. PMID: 1397722
Cited by
-
Prolactin levels, endothelial dysfunction, and the risk of cardiovascular events and mortality in patients with CKD.Clin J Am Soc Nephrol. 2012 Feb;7(2):207-15. doi: 10.2215/CJN.06840711. Epub 2011 Dec 22. Clin J Am Soc Nephrol. 2012. PMID: 22193237 Free PMC article.
-
Endothelium-derived relaxing factor inhibits the endothelin-1-induced increase in protein kinase C activity in rat aorta.Br J Pharmacol. 1991 Sep;104(1):139-44. doi: 10.1111/j.1476-5381.1991.tb12398.x. Br J Pharmacol. 1991. PMID: 1838492 Free PMC article.
-
Urinary incontinence as a novel and underrecognized clinical manifestation of prolactinoma in women.Pituitary. 2025 Aug 30;28(5):96. doi: 10.1007/s11102-025-01567-4. Pituitary. 2025. PMID: 40884590
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
