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. 2016 Jun 15;4(2):219-25.
doi: 10.3889/oamjms.2016.043. Epub 2016 May 24.

Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate

Samia M Sami  1 , Iman I Salama  2 , Ghada A Abdel-Latif  2 , Lobna A El Etreby  2 , Ahmed I Metwally  2 , Naglaa F Abd El Haliem  3
Affiliations

Hepatitis B Seroprotection and the Response to a Challenging Dose among Vaccinated Children in Red Sea Governorate

Samia M Sami et al. Open Access Maced J Med Sci. .

Abstract

Aim: To assess the long-term effectiveness of hepatitis B virus vaccine and the need for a booster dose among children who received three doses of vaccine during infancy in Red Sea Governorate.

Methods: A cross-sectional study was performed. Interviews with children (9 months to 16 years) and parents were done. Blood samples to assess Hepatitis B markers were tested. Children showing no seroprotection received a booster dose to assess their anamnestic response after four weeks and one year later.

Results: None of the participants had evidence of chronic Hepatitis B. The seroprotection rate was 23.3% and it significantly decreased with age. Multivariate logistic analysis revealed that older age was the significant predicting variable for having no seroprotective level, while baseline anti-HBs level < 3.3 IU/L was the predicting variable for not developing early anamnestic response or loss of late anamnestic response.

Conclusion: Long-term immunity persists among children who received complete series of hepatitis B vaccination during infancy even in absence or reduction of anti-HBs over time. Therefore, a booster dose is not necessary to maintain immunity till the age of sixteen.

Keywords: Anamnestic response; Booster dose; Children; Egypt; HBV vaccine; Seroprotection.

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Figures

Figure 1
Figure 1
Baseline seroprotection and early anamnestic response rates among the studied children.
See this image and copyright information in PMC

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