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. 2015 Jun 8:2:2333794X15590149.
doi: 10.1177/2333794X15590149. eCollection 2015.

Botulinum Toxin in Pediatric Neurology: Switching Lanes From Death to Life

Eman M I Moawad  1 , Enas Abdallah Ali Abdallah  1
Affiliations

Botulinum Toxin in Pediatric Neurology: Switching Lanes From Death to Life

Eman M I Moawad et al. Glob Pediatr Health. .

Abstract

Botulinum neurotoxins are natural molecules produced by anaerobic spore-forming bacteria called Clostradium boltulinum. The toxin has a peculiar mechanism of action by preventing the release of acetylcholine from the presynaptic membrane. Consequently, it has been used in the treatment of various neurological conditions related to muscle hyperactivity and/or spasticity. Also, it has an impact on the autonomic nervous system by acting on smooth muscle, leading to its use in the management of pain syndromes. The use of botulinum toxin in children separate from adults has received very little attention in the literature. This review presents the current data on the use of botulinum neurotoxin to treat various neurological disorders in children.

Keywords: botulinum toxin; children; neurological uses.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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