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. 2015 Oct 7:2:2333794X15607798.
doi: 10.1177/2333794X15607798. eCollection 2015.

Impact of Age, Gender, and Addition of Probiotics on Treatment Success for Helicobacter pylori in Children

Noam Weiner  1 , Ron Shaoul  1
Affiliations

Impact of Age, Gender, and Addition of Probiotics on Treatment Success for Helicobacter pylori in Children

Noam Weiner et al. Glob Pediatr Health. .

Abstract

The primary objective of this study was to evaluate the effect of age, gender, and the use of probiotics with standard treatment regimen on Helicobacter pylori eradication. Based on endoscopic findings and clinical presentation, selected patients were treated with standard triple therapy (omeprazole, clarithromycin, and amoxicillin). Those who failed were offered a repeat treatment with omeprazole, metronidazole, and amoxicillin. After the publications of the possible advantages of probiotic treatment on H pylori eradication, the probiotic agent "Probiotica Forte" was routinely added to the treatment. Eradication was noted for 94/130 patients (72%) and for 128/197 patients (65%) with or without probiotic agent, respectively (P = .23). For second-line treatment eradication was noted in 33/46 (72%) and in 9/20 (45%) with or without probiotic agent, respectively (P = .053). The addition of probiotics may improve eradication success especially in addition to second-line treatment.

Keywords: Helicobacter pylori; children; eradication; probiotics; treatment.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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