This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

. 2016 Jun 23;7(6):e2270.

doi: 10.1038/cddis.2016.174.

Towards maximising information extraction from rodent models of ocular disease

B M Davis¹, L Guo¹, J Brenton¹, L Langley¹, E M Normando², M F Cordeiro^{1

2}

Affiliations

Affiliations

¹ Glaucoma and Retinal Neurodegeneration Research, Visual Neuroscience, UCL Institute of Ophthalmology, London, UK.
² Western Eye Hospital, Imperial College Healthcare Trust, London, UK.

PMID: 27336714
PMCID: PMC5143400
DOI: 10.1038/cddis.2016.174

Towards maximising information extraction from rodent models of ocular disease

B M Davis et al. Cell Death Dis. 2016.

. 2016 Jun 23;7(6):e2270.

doi: 10.1038/cddis.2016.174.

Authors

B M Davis¹, L Guo¹, J Brenton¹, L Langley¹, E M Normando², M F Cordeiro^{1

2}

Affiliations

¹ Glaucoma and Retinal Neurodegeneration Research, Visual Neuroscience, UCL Institute of Ophthalmology, London, UK.
² Western Eye Hospital, Imperial College Healthcare Trust, London, UK.

PMID: 27336714
PMCID: PMC5143400
DOI: 10.1038/cddis.2016.174

No abstract available

PubMed Disclaimer

Figures

Figure 1
Maximising the extraction of information from retinal whole-mounts. (a) Brn-3a retinal whole-mounts were obtained at different timeponts from established rodent models of optic neuropathy. (b) The algorithm we developed first segmented the RGC population from these whole-mounts before spatially segmenting the population into a series 60 of non-overlapping sectors defined relative to the position of the optic nerve head. (c) Assessment of longitudinal changes across the natural history of each model permitted the spatial-patterns in RGC density changes, half-life and the extent of primary degeneration to be evaluated and summarised as colourmaps

See this image and copyright information in PMC

Similar articles

N-methyl-D-aspartate (NMDA)-mediated excitotoxic damage: a mouse model of acute retinal ganglion cell damage.
Seitz R, Tamm ER. Seitz R, et al. Methods Mol Biol. 2013;935:99-109. doi: 10.1007/978-1-62703-080-9_7. Methods Mol Biol. 2013. PMID: 23150363
Myelinated Retinal Nerve Fiber Layer (RNFL): A Comprehensive Review.
Ramkumar HL, Verma R, Ferreyra HA, Robbins SL. Ramkumar HL, et al. Int Ophthalmol Clin. 2018 Fall;58(4):147-156. doi: 10.1097/IIO.0000000000000239. Int Ophthalmol Clin. 2018. PMID: 30239369 Review. No abstract available.
Full-Field Electroretinogram Responses in Rodent Models of Ganglion Cell Injury.
Zhao D, Lee PY, Wong VHY, Hoang A, Tran KKN, Van Koeverden AK, Afiat BC, Nguyen CTO, Bui BV. Zhao D, et al. Methods Mol Biol. 2025;2858:207-218. doi: 10.1007/978-1-0716-4140-8_17. Methods Mol Biol. 2025. PMID: 39433678
GM1 gangliosidosis, type 2: ocular clinicopathologic correlation.
Cairns LJ, Green WR, Singer HS. Cairns LJ, et al. Graefes Arch Clin Exp Ophthalmol. 1984;222(2):51-62. doi: 10.1007/BF02150632. Graefes Arch Clin Exp Ophthalmol. 1984. PMID: 6440832
Rodent Models of Retinal Degeneration: From Purified Cells in Culture to Living Animals.
Fradot V, Augustin S, Fontaine V, Marazova K, Guillonneau X, Sahel JA, Picaud S. Fradot V, et al. Cold Spring Harb Perspect Med. 2024 Oct 1;14(10):a041311. doi: 10.1101/cshperspect.a041311. Cold Spring Harb Perspect Med. 2024. PMID: 37848250 Review.

See all similar articles

Cited by

Dynamic changes in cell size and corresponding cell fate after optic nerve injury.
Davis BM, Guo L, Ravindran N, Shamsher E, Baekelandt V, Mitchell H, Bharath AA, De Groef L, Cordeiro MF. Davis BM, et al. Sci Rep. 2020 Dec 10;10(1):21683. doi: 10.1038/s41598-020-77760-1. Sci Rep. 2020. PMID: 33303775 Free PMC article.
Topical Curcumin Nanocarriers are Neuroprotective in Eye Disease.
Davis BM, Pahlitzsch M, Guo L, Balendra S, Shah P, Ravindran N, Malaguarnera G, Sisa C, Shamsher E, Hamze H, Noor A, Sornsute A, Somavarapu S, Cordeiro MF. Davis BM, et al. Sci Rep. 2018 Jul 23;8(1):11066. doi: 10.1038/s41598-018-29393-8. Sci Rep. 2018. PMID: 30038334 Free PMC article.
Characterizing microglia activation: a spatial statistics approach to maximize information extraction.
Davis BM, Salinas-Navarro M, Cordeiro MF, Moons L, De Groef L. Davis BM, et al. Sci Rep. 2017 May 8;7(1):1576. doi: 10.1038/s41598-017-01747-8. Sci Rep. 2017. PMID: 28484229 Free PMC article.
Topical Coenzyme Q10 demonstrates mitochondrial-mediated neuroprotection in a rodent model of ocular hypertension.
Davis BM, Tian K, Pahlitzsch M, Brenton J, Ravindran N, Butt G, Malaguarnera G, Normando EM, Guo L, Cordeiro MF. Davis BM, et al. Mitochondrion. 2017 Sep;36:114-123. doi: 10.1016/j.mito.2017.05.010. Epub 2017 May 24. Mitochondrion. 2017. PMID: 28549843 Free PMC article.
Topical recombinant human Nerve growth factor (rh-NGF) is neuroprotective to retinal ganglion cells by targeting secondary degeneration.
Guo L, Davis BM, Ravindran N, Galvao J, Kapoor N, Haamedi N, Shamsher E, Luong V, Fico E, Cordeiro MF. Guo L, et al. Sci Rep. 2020 Feb 25;10(1):3375. doi: 10.1038/s41598-020-60427-2. Sci Rep. 2020. PMID: 32099056 Free PMC article.

References

1. Tham Y et al Am Acad Ophthalmol 2014; 121: 2081–2090. - PubMed
1. Anderson DR et al Am J Ophthalmol 1998; 126: 487–497. - PubMed
1. Chang EE et al Ophthalmology 2012; 119: 979–986. - PMC - PubMed
1. Titchenell PM et al Diabetes 2013; 62: 1808–1815. - PMC - PubMed
1. Russell WMS et al The principles of humane experimental technique. Methuen & Co. Ltd.: London, 1959.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Consumer Health Information
- MedlinePlus Health Information