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. 2016 Jun 23;7(6):e2276.
doi: 10.1038/cddis.2016.183.

The APRIL paradox in normal versus malignant B cell biology

M H A van Attekum  1   2 , A P Kater  1   3 , E Eldering  2   3
Affiliations

The APRIL paradox in normal versus malignant B cell biology

M H A van Attekum et al. Cell Death Dis. .
No abstract available

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Figures

Figure 1
Figure 1
APRIL effects at different stages of B cell development and in CLL. Depending on the developmental stage of B cells, APRIL stimulation results in different outcomes. Although APRIL induces the survival of plasma cells for instance, it has no effect on survival in other stages. As CLL cells are derived from precursor B cells – namely memory B cells or B1 cells – that are unaffected by APRIL with respect to survival, proliferation or NF-κB activation, the overlap in differentiation program could explain the absence of direct effects on CLL cells that we have reported in Cell Death and Discovery. It can, however, not be excluded that APRIL exerts its effect on CLL cells indirectly via other cell types. Stimulation of TACI in B1 cells by BAFF has recently been shown to induce IL-10 production in these cells, which could result in immune-suppressive signaling, thereby mitigating cytotoxic T-cell responses to the malignant cells. Numbers in boxes denote references. Arrows and lines denote positive effect, no effect or no reported effect of APRIL. CSR, class-switch recombination; GC, germinal center; MEM, memory; prod, production
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