Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jul 18;55(30):8502-27.
doi: 10.1002/anie.201601524. Epub 2016 Jun 23.

Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture)

Aziz Sancar  1
Affiliations
Review

Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture)

Aziz Sancar. Angew Chem Int Ed Engl. .

Abstract

Ultraviolet light damages DNA by converting two adjacent thymines into a thymine dimer which is potentially mutagenic, carcinogenic, or lethal to the organism. This damage is repaired by photolyase and the nucleotide excision repair system in E. coli by nucleotide excision repair in humans. The work leading to these results is presented by Aziz Sancar in his Nobel Lecture.

Keywords: Maxicell method; circadian clock; cryptochrome; nucleotide excision repair; photoreactivation.

PubMed Disclaimer

MeSH terms

LinkOut - more resources