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Clinical Trial
. 2016 Jun 23;14(1):166.
doi: 10.1186/s12957-016-0915-4.

Non-primary breast malignancies: a single institution's experience of a diagnostic challenge with important therapeutic consequences-a retrospective study

Florian E Buisman  1   2 , Linda van Gelder  3 , Marian B E Menke-Pluijmers  3 , Bob H C Bisschops  4 , Peter W Plaisier  3 , Pieter J Westenend  5
Affiliations
Clinical Trial

Non-primary breast malignancies: a single institution's experience of a diagnostic challenge with important therapeutic consequences-a retrospective study

Florian E Buisman et al. World J Surg Oncol. .

Abstract

Background: Breast cancer is a common malignancy, but metastases to the breast of extramammary malignancies are very rare. Treatment and prognosis are different. The aim of the study is to report the incidence of lymphomas and metastases to the breast of extramammary malignancies in our 30-year archive.

Methods: The pathology database of a single institute was reviewed for all breast neoplasms which were coded in our system as a metastasis in the period 1985-2014. Metastatic tumors from primary breast carcinoma were excluded.

Results: A total of 47 patients were included (7 men/40 women, mean age 63 years). The majority originated from lymphoma (n = 18) and primary melanoma (n = 11). Other primary tumor sites included the ovary (n = 6), lung (n = 6), colon (n = 3), kidney (n = 1), stomach (n = 1), and chorion (n = 1). In 24/47 patients (51 %), metastasis was the first sign of the specific malignant disease. In seven patients (15 %) surgery was performed, the diagnosis of metastatic disease was adjusted in four patients (9 %) postoperatively.

Conclusions: It is important to distinguish lymphomas and metastases to the breast from common primary breast carcinoma for proper treatment and prognosis. Therefore, we emphasize the need for a histological or cytopathological diagnosis before any treatment is commenced. The pathologist plays a key role in considering the diagnosis of metastasis if the histological features are unusual for a primary breast carcinoma. The pathologist should therefore be properly informed by the clinical physician although lymphomas and metastases to the breast are the first presentation of malignant disease in half the cases.

Keywords: Breast; Malignancies; Metastases.

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References

    1. Hajdu SI, Urban JA. Cancers metastatic to the breast. Cancer. 1972;29(6):1691–1696. doi: 10.1002/1097-0142(197206)29:6<1691::AID-CNCR2820290637>3.0.CO;2-4. - DOI - PubMed
    1. McCrea ES, Johnston C, Haney PJ. Metastases to the breast. AJR Am J Roentgenol. 1983;141(4):685–690. doi: 10.2214/ajr.141.4.685. - DOI - PubMed
    1. Alva S, Shetty-Alva N. An update of tumor metastasis to the breast data. Arch Surg. 1999;134(4):450. doi: 10.1001/archsurg.134.4.450. - DOI - PubMed
    1. Williams SA, Ehlers RA, 2nd, Hunt KK, Yi M, Kuerer HM, Singletary SE, et al. Metastases to the breast from nonbreast solid neoplasms: presentation and determinants of survival. Cancer. 2007;110(4):731–737. doi: 10.1002/cncr.22835. - DOI - PubMed
    1. van Rossen ME, Westenend PJ, Plaisier PW. Response to “Breast metastases from colorectal carcinoma” by R. Mihai et al. The Breast 2004; 13, 155-8. Breast. 2005;14(1):80–81. - PubMed

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