Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2016 Sep;114(3):375-9.
doi: 10.1002/jso.24327. Epub 2016 Jun 23.

Complete metastasectomy for renal cell carcinoma: Comparison of five solid organ sites

Christopher D Jakubowski  1 , Emily A Vertosick  2 , Brian R Untch  3 , Daniel Sjoberg  2 , Elizabeth Wei  1 , Frank L Palmer  3 , Snehal G Patel  4 , Robert J Downey  5 , Vivian E Strong  3 , Paul Russo  1
Affiliations
Comparative Study

Complete metastasectomy for renal cell carcinoma: Comparison of five solid organ sites

Christopher D Jakubowski et al. J Surg Oncol. 2016 Sep.

Abstract

Background and objectives: Patients with metastatic RCC can undergo metastasectomy to improve survival time. Our goal was to provide and compare characteristics and oncological outcomes of RCC patients who underwent complete metastasectomy at a single organ site.

Methods: A total of 138 RCC patients were identified as undergoing complete metastasectomy at a single organ site including adrenal, lung, liver, pancreas, or thyroid. Competing risk regression analysis was used to assess RFS and CSS adjusting for several covariates.

Results: In this highly selected cohort, RFS and CSS was 27% and 84% at 5 years following metastasectomy, respectively. Univariate analysis revealed that removal of multiple tumors, younger age, and a shorter interval between nephrectomy and metastasis was associated with worse RFS. Larger tumors and sarcomatoid histology at nephrectomy was associated with worse CSS. We found no evidence that metastases at the time of RCC diagnosis influenced recurrence or survival. Tumor size, number of metastases resected, and time from nephrectomy to first recurrence was significantly different, but recurrence rates were not found to be significantly different, when compared across all organ sites.

Conclusions: These findings inform clinical and surgical management of select RCC patients with isolated metastasis to one of several organ sites. J. Surg. Oncol. 2016;114:375-379. © 2016 Wiley Periodicals, Inc.

Keywords: adrenal; liver; lung; metastasectomy for renal cell carcinoma; pancreas; thyroid.

PubMed Disclaimer

Figures

Figure I
Figure I
Cohort selection schematic.
Figure II
Figure II
A. Kaplan-Meier survival estimates with 95% CI for RFS after metastasectomy. B. Kaplan-Meier survival estimates with 95% CI for CSS after metastasectomy.
See this image and copyright information in PMC

References

    1. Flanigan RC, Campbell SC, Clark JI, Picken MM. Metastatic renal cell carcinoma. Curr Treat Options Oncol. 2003;4:385–390. doi: 10.1007/s11864-003-0039-2. - DOI - PubMed
    1. Swanson DA. Surgery for metastases of renal cell carcinoma. Scand J Surg SJS Off Organ Finn Surg Soc Scand Surg Soc. 2004;93:150–155. - PubMed
    1. Eggener SE, Yossepowitch O, Kundu S, Motzer RJ, Russo P. Risk score and metastasectomy independently impact prognosis of patients with recurrent renal cell carcinoma. J Urol. 2008;180:873–878. doi: 10.1016/j.juro.2008.05.006. discussion 878. - DOI - PMC - PubMed
    1. Kavolius JP, Mastorakos DP, Pavlovich C, Russo P, Burt ME, Brady MS. Resection of metastatic renal cell carcinoma. J Clin Oncol Off J Am Soc Clin Oncol. 1998;16:2261–2266. - PubMed
    1. Kierney PC, van Heerden JA, Segura JW, Weaver AL. Surgeon’s role in the management of solitary renal cell carcinoma metastases occurring subsequent to initial curative nephrectomy: an institutional review. Ann Surg Oncol. 1994;1:345–352. - PubMed

Publication types

MeSH terms