The Effect of a Gluten-Free Diet in Children With Difficult-to-Manage Nephrotic Syndrome

doi:10.1542/peds.2015-4528

Case Reports

. 2016 Jul;138(1):e20154528.

doi: 10.1542/peds.2015-4528.

The Effect of a Gluten-Free Diet in Children With Difficult-to-Manage Nephrotic Syndrome

Kevin V Lemley¹, Christian Faul², Karla Schramm², Kevin Meyers³, Frederick Kaskel⁴, Katherine M Dell⁵, Debbie S Gipson⁶, Keisha Gibson⁷, Howard Trachtman⁸

Affiliations

¹ Division of Nephrology, Children's Hospital Los Angeles, Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California;
² Division of Nephrology and Hypertension, Department of Medicine and Department of Cell Biology and Anatomy, University of Miami Leonard M. Miller School of Medicine, Miami, Florida;
³ Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania;
⁴ Division of Nephrology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York;
⁵ Center for Pediatric Nephrology, Department of Pediatrics, Cleveland Clinic Children's, Case Western Reserve University, Cleveland, Ohio;
⁶ Division of Nephrology, Department of Pediatrics, CS Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan;
⁷ Division of Nephrology, Department of Medicine and Pediatrics, University of North Carolina, Chapel Hill, North Carolina;and.
⁸ Division of Nephrology, Department of Pediatrics, NYU Langone Medical Center, NYU School of Medicine, New York, New York howard.trachtman@nyumc.org.

PMID: 27338701
PMCID: PMC4983765
DOI: 10.1542/peds.2015-4528

Case Reports

The Effect of a Gluten-Free Diet in Children With Difficult-to-Manage Nephrotic Syndrome

Kevin V Lemley et al. Pediatrics. 2016 Jul.

. 2016 Jul;138(1):e20154528.

doi: 10.1542/peds.2015-4528.

Authors

Kevin V Lemley¹, Christian Faul², Karla Schramm², Kevin Meyers³, Frederick Kaskel⁴, Katherine M Dell⁵, Debbie S Gipson⁶, Keisha Gibson⁷, Howard Trachtman⁸

Affiliations

¹ Division of Nephrology, Children's Hospital Los Angeles, Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California;
² Division of Nephrology and Hypertension, Department of Medicine and Department of Cell Biology and Anatomy, University of Miami Leonard M. Miller School of Medicine, Miami, Florida;
³ Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania;
⁴ Division of Nephrology, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York;
⁵ Center for Pediatric Nephrology, Department of Pediatrics, Cleveland Clinic Children's, Case Western Reserve University, Cleveland, Ohio;
⁶ Division of Nephrology, Department of Pediatrics, CS Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan;
⁷ Division of Nephrology, Department of Medicine and Pediatrics, University of North Carolina, Chapel Hill, North Carolina;and.
⁸ Division of Nephrology, Department of Pediatrics, NYU Langone Medical Center, NYU School of Medicine, New York, New York howard.trachtman@nyumc.org.

PMID: 27338701
PMCID: PMC4983765
DOI: 10.1542/peds.2015-4528

Abstract

Case reports have linked childhood nephrotic syndrome to food sensitivity, including gluten. We report our experience with 8 children (6 boys, 2 girls; age at implementation of special diet 2-14 years) with difficult-to-manage nephrotic syndrome who were placed on a gluten-free diet for 3.4 ± 4.3 years (range, 0.6-14 years) and who had clinical improvement enabling reduction or discontinuation in steroid dosage.

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Conflict of interest statement

POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.

FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.

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References

1. Metz DK, Kausman JY. Childhood nephrotic syndrome in the 21st century: what’s new? J Paediatr Child Health. 2014;51:497–504 - PubMed
1. Gipson DS, Massengill SF, Yao L, et al. . Management of childhood onset nephrotic syndrome. Pediatrics. 2009;124(2):747–757 - PubMed
1. Uy N, Graf L, Lemley KV, Kaskel F. Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome and gut microbiota. Pediatr Res. 2015;77(1–2):252–255 - PMC - PubMed
1. Sandberg DH, Bernstein CW, McIntosh RM, Carr R, Strauss J. Severe steroid-responsive nephrosis associated with hypersensitivity. Lancet. 1977;1(8008):388–391 - PubMed
1. Lagrue G, Laurent J, Rostoker G. Food allergy and idiopathic nephrotic syndrome. Kidney Int Suppl. 1989;27(suppl):S147–S151 - PubMed

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[1] Metz DK, Kausman JY. Childhood nephrotic syndrome in the 21st century: what’s new? J Paediatr Child Health. 2014;51:497–504 - PubMed

[2] Metz DK, Kausman JY. Childhood nephrotic syndrome in the 21st century: what’s new? J Paediatr Child Health. 2014;51:497–504 - PubMed

[3] Gipson DS, Massengill SF, Yao L, et al. . Management of childhood onset nephrotic syndrome. Pediatrics. 2009;124(2):747–757 - PubMed

[4] Gipson DS, Massengill SF, Yao L, et al. . Management of childhood onset nephrotic syndrome. Pediatrics. 2009;124(2):747–757 - PubMed

[5] Uy N, Graf L, Lemley KV, Kaskel F. Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome and gut microbiota. Pediatr Res. 2015;77(1–2):252–255 - PMC - PubMed

[6] Uy N, Graf L, Lemley KV, Kaskel F. Effects of gluten-free, dairy-free diet on childhood nephrotic syndrome and gut microbiota. Pediatr Res. 2015;77(1–2):252–255 - PMC - PubMed

[7] Sandberg DH, Bernstein CW, McIntosh RM, Carr R, Strauss J. Severe steroid-responsive nephrosis associated with hypersensitivity. Lancet. 1977;1(8008):388–391 - PubMed

[8] Sandberg DH, Bernstein CW, McIntosh RM, Carr R, Strauss J. Severe steroid-responsive nephrosis associated with hypersensitivity. Lancet. 1977;1(8008):388–391 - PubMed

[9] Lagrue G, Laurent J, Rostoker G. Food allergy and idiopathic nephrotic syndrome. Kidney Int Suppl. 1989;27(suppl):S147–S151 - PubMed

[10] Lagrue G, Laurent J, Rostoker G. Food allergy and idiopathic nephrotic syndrome. Kidney Int Suppl. 1989;27(suppl):S147–S151 - PubMed

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The Effect of a Gluten-Free Diet in Children With Difficult-to-Manage Nephrotic Syndrome

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The Effect of a Gluten-Free Diet in Children With Difficult-to-Manage Nephrotic Syndrome

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