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Review
. 2016 Sep;17(3):287-294.
doi: 10.1007/s11154-016-9369-9.

Neuroendocrinology of the skin

Theoharis C Theoharides  1   2   3 , Julia M Stewart  4 , Alexandra Taracanova  4   5 , Pio Conti  6 , Christos C Zouboulis  7
Affiliations
Review

Neuroendocrinology of the skin

Theoharis C Theoharides et al. Rev Endocr Metab Disord. 2016 Sep.

Abstract

The skin is considered the mirror of the soul and is affected by neurohormonal triggers, especially stress. Hair follicles, keratinocytes, mast cells, melanocytes, and sebocytes all express sex and stress hormones implicating them in a local "hypothalamic-pituitary-adrenal axis." In particular, the peptides corticotropin-releasing hormone (CRH) and neurotensin (NT) have synergistic action stimulating mast cells and are uniquely elevated in the serum of patients with skin diseases exacerbated by stress. Addressing the neurohormonal regulation of skin function could lead to new targets for effective treatment of inflammatory skin diseases.

Keywords: Corticotropin-releasing hormone; Hypothalamic-pituitary-adrenal axis; Neuroendocrinology; Neurotensin; Skin.

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