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Comment
. 2016 Aug;8(4):369-70.
doi: 10.1093/jmcb/mjw031. Epub 2016 Jun 23.

BTG4, a maternal mRNA cleaner

Di Wu  1 , Jurrien Dean  2
Affiliations
Comment

BTG4, a maternal mRNA cleaner

Di Wu et al. J Mol Cell Biol. 2016 Aug.
No abstract available

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Figures

Figure 1
Figure 1
BTG4-dependent maternal RNA clearance during oocyte maturation. Oocytes grow within the ovary and are ovulated into the oviduct where they are fertilized. Asymmetric meiotic divisions form polar bodies (PBs) present in the perivitelline space between the zona pellucida and the plasma membrane. During oocyte growth, maternal mRNAs accumulate, but are largely degraded during and after oocyte maturation. Rapid and efficient clearance of the majority of maternal mRNAs is required for normal embryonic development. Mouse BTG4 fosters maternal RNA degradation by recruiting the RNA de-adenylation complex CCR4-NOT onto target mRNAs and the de-adenylated mRNAs are subsequently degraded by RNA exonucleases.
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References

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