Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jun 23;4(3):e00607-16.
doi: 10.1128/genomeA.00607-16.

Complete Genome Sequence of the First KPC-Type Carbapenemase-Positive Proteus mirabilis Strain from a Bloodstream Infection

Vincenzo Di Pilato  1 , Adriana Chiarelli  2 , Christine J Boinett  3 , Eleonora Riccobono  4 , Simon R Harris  3 , Marco Maria D'Andrea  2 , Nicholas R Thomson  3 , Gian Maria Rossolini  5 , Tommaso Giani  6
Affiliations

Complete Genome Sequence of the First KPC-Type Carbapenemase-Positive Proteus mirabilis Strain from a Bloodstream Infection

Vincenzo Di Pilato et al. Genome Announc. .

Abstract

Sequencing of the blaKPC-positive strain Proteus mirabilis AOUC-001 was performed using both the MiSeq and PacBio RS II platforms and yielded a single molecule of 4,272,433 bp, representing the complete chromosome. Genome analysis showed the presence of several acquired resistance determinants, including two copies of blaKPC-2 carried on a fragment of a KPC-producing plasmid previously described in Klebsiella pneumoniae.

PubMed Disclaimer

References

    1. O’Hara CM, Brenner FW, Miller JM. 2000. Classification, identification, and clinical significance of Proteus, Providencia, and Morganella. Clin Microbiol Rev 13:534–546. doi: 10.1128/CMR.13.4.534-546.2000. - DOI - PMC - PubMed
    1. Rossolini GM. 2015. Extensively drug-resistant carbapenemase-producing Enterobacteriaceae producing carbapenemases: an emerging challenge for clinicians and healthcare systems. J Intern Med 277:528–531. doi: 10.1111/joim.12350. - DOI - PubMed
    1. Hargreaves ML, Shaw KM, Dobbins G, Snippes Vagnone PM, Harper JE, Boxrud D, Lynfield R, Aziz M, Price LB, Silverstein KAT, Danzeisen JL, Youmans B, Case K, Sreevatsan S, Johnson TJ. 2015. Clonal dissemination of Enterobacter cloacae harboring blaKPC-3 in the upper midwestern United States. Antimicrob Agents Chemother 59:7723–7734. doi: 10.1128/AAC.01291-15. - DOI - PMC - PubMed
    1. Robledo IE, Aquino EE, Santé MI, Santana JL, Otero DM, León CF, Vázquez GJ. 2010. Detection of KPC in Acinetobacter spp. in Puerto Rico. Antimicrob Agents Chemother 54:1354–1357. doi: 10.1128/AAC.00899-09. - DOI - PMC - PubMed
    1. Villegas M-V, Lolans K, Correa A, Kattan JN, Lopez JA, Quinn JP, the Colombian Nosocomial Resistance Study Group . 2007. First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing β-lactamase. Antimicrob Agents Chemother 51:1553–1555. doi: 10.1128/AAC.01405-06. - DOI - PMC - PubMed

LinkOut - more resources