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Multicenter Study
. 2016 Sep 7;11(9):1590-1596.
doi: 10.2215/CJN.02540316. Epub 2016 Jun 23.

Risk Factors for and Outcomes of Catheter-Associated Peritonitis in Children: The SCOPE Collaborative

Christine B Sethna  1 , Kristina Bryant  2 , Raj Munshi  3 , Bradley A Warady  4 , Troy Richardson  5 , John Lawlor  5 , Jason G Newland  6 , Alicia Neu  7 ; SCOPE Investigators
Affiliations
Multicenter Study

Risk Factors for and Outcomes of Catheter-Associated Peritonitis in Children: The SCOPE Collaborative

Christine B Sethna et al. Clin J Am Soc Nephrol. .

Abstract

Background and objectives: The Standardizing Care to Improve Outcomes in Pediatric ESRD Collaborative is a quality improvement initiative that aims to reduce peritoneal dialysis-associated infections in pediatric patients on chronic peritoneal dialysis. Our objectives were to determine whether provider compliance with peritoneal dialysis catheter care bundles was associated with lower risk for infection at the individual patient level and describe the epidemiology, risk factors, and outcomes for peritonitis in the Standardizing Care to Improve Outcomes in Pediatric ESRD Collaborative.

Design, setting, participants, & measurements: We collected peritoneal dialysis characteristics, causative organisms, compliance with care bundles, and outcomes in children with peritonitis between October of 2011 and September of 2014. Chi-squared tests, t tests, and generalized linear mixed models were used to assess risk factors for peritonitis.

Results: Of 734 children enrolled (54% boys; median age =9 years old; interquartile range, 1-15) from 29 centers, 391 peritonitis episodes occurred among 245 individuals over 10,130 catheter-months. The aggregate annualized peritonitis rate was 0.46 episodes per patient-year. Rates were highest among children ≤2 years old (0.62 episodes per patient-year). Gram-positive peritonitis predominated (37.8%) followed by culture-negative (24.7%), gram-negative (19.5%), and polymicrobial (10.3%) infections; fungal only peritonitis accounted for 7.7% of episodes. Compliance with the follow-up bundle was associated with a lower rate of peritonitis (rate ratio, 0.49; 95% confidence interval, 0.30 to 0.80) in the multivariable model. Upward orientation of the catheter exit site (rate ratio, 4.2; 95% confidence interval, 1.49 to 11.89) and touch contamination (rate ratio, 2.22; 95% confidence interval, 1.44 to 3.34) were also associated with a higher risk of peritonitis. Infection outcomes included resolution with antimicrobial treatment alone in 76.6%, permanent catheter removal in 12.2%, and catheter removal with return to peritoneal dialysis in 6% of episodes.

Conclusions: Lower compliance with standardized practices for follow-up peritoneal dialysis catheter care in the Standardizing Care to Improve Outcomes in Pediatric ESRD Collaborative was associated with higher risk of peritonitis. Quality improvement and prevention strategies have the potential to reduce peritoneal dialysis-associated peritonitis.

Keywords: Follow-Up Studies; Humans; Kidney Failure, Chronic; Patient Care Bundles; Quality Improvement; catheter-related infections; children; peritoneal dialysis; peritonitis; renal dialysis; risk factors.

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Figures

Figure 1.
Figure 1.
Organisms cultured from patients with peritonitis. Gram-positive organisms were the predominant bacteria in peritonitis (n=389 cultures; missing two cultures; may have more than one pathogen per peritonitis episode). E. coli, Escherichia coli; MRSA, Methicillin-resistant Staphylococcus aureus; Staph, Staphylococcus; Staph A, Staphylococcus aureus; Staph Epi, Staphylococcus epidermidis.
Figure 2.
Figure 2.
Outcomes of peritonitis by organism.
See this image and copyright information in PMC

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