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. 2015 Apr;6(2 Suppl):4S-12S.
doi: 10.1177/1947603514536983. Epub 2015 Mar 24.

Cellular and Acellular Approaches for Cartilage Repair: A Philosophical Analysis

Mats Brittberg  1
Affiliations

Cellular and Acellular Approaches for Cartilage Repair: A Philosophical Analysis

Mats Brittberg. Cartilage. 2015 Apr.

Abstract

There are several choices of cells to use for cartilage repair. Cells are used as internal or external sources and sometimes in combination. In this article, an analysis of the different cell choices and their use and potential is provided. Embryonic cartilage formation is of importance when finding more about how to be able to perfect cartilage repair. Some suggestions for near future research based on up-to-date knowledge on chondrogenic cells are given to hopefully stimulate more studies on the final goal of cartilage regeneration.

Keywords: chondrocytes; chondrogenic; stem cells.

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Conflict of interest statement

Declaration of Conflicting Interests: The author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
(A) A multilayered scaffold with different cells in different layers, influenced by mechanical forces and cross-talking between the cells in the layers, the neighboring native cells, and signals from subchondral bone. (B) The cell-seeded scaffold has matured into osteochondral repair tissue, slowly being integrated into the defect area during the maturation process. (C) Total repair (almost regeneration).
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