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Review
. 2016 Oct;38(10):1665-72.
doi: 10.1007/s10529-016-2163-7. Epub 2016 Jun 24.

The importance of stem cell engineering in head and neck oncology

Wojciech Barczak  1   2 , Pawel Golusiński  1 , Lukasz Luczewski  1 , Wiktoria M Suchorska  3   4 , Michal M Masternak  1   5 , Wojciech Golusiński  1
Affiliations
Review

The importance of stem cell engineering in head and neck oncology

Wojciech Barczak et al. Biotechnol Lett. 2016 Oct.

Abstract

Head and neck squamous cell carcinoma is the sixth leading cause of cancer worldwide. The most common risk factors are carcinogens (tobacco, alcohol), and infection of the human papilloma virus. Surgery is still considered as the treatment of choice in case of head and neck cancer, followed by a reconstructive surgery to enhance the quality of life in the patients. However, the widespread use of artificial implants does not provide appropriate physiological activities and often cannot act as a long-term solution for the patients. Here we review the applicability of multiple stem cell types for tissue engineering of cartilage, trachea, vocal folds and nerves for head and neck injuries. The ability of the cells to self-renew and maintain their pluripotency state makes them an attractive tool in tissue engineering.

Keywords: HESC; Head and neck cancer; Induced pluripotent stem cells; Mesenchymal stem cells; Stem cell tissue engineering.

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Conflict of interest statement

The authors declare that they have no competing interests.

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