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. 1989 Jun;86(12):4412-5.
doi: 10.1073/pnas.86.12.4412.

A tool for multiple sequence alignment

D J Lipman  1 , S F Altschul, J D Kececioglu
Affiliations

A tool for multiple sequence alignment

D J Lipman et al. Proc Natl Acad Sci U S A. 1989 Jun.

Abstract

Multiple sequence alignment can be a useful technique for studying molecular evolution and analyzing sequence-structure relationships. Until recently, it has been impractical to apply dynamic programming, the most widely accepted method for producing pairwise alignments, to comparisons of more than three sequences. We describe the design and application of a tool for multiple alignment of amino acid sequences that implements a new algorithm that greatly reduces the computational demands of dynamic programming. This tool is able to align in reasonable time as many as eight sequences the length of an average protein.

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