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. 1989 Jun;86(12):4416-20.
doi: 10.1073/pnas.86.12.4416.

Two peptides related to platelet-derived growth factor are present in human wound fluid

J Matsuoka  1 , G R Grotendorst
Affiliations

Two peptides related to platelet-derived growth factor are present in human wound fluid

J Matsuoka et al. Proc Natl Acad Sci U S A. 1989 Jun.

Abstract

Platelet-derived growth factor (PDGF) has been suggested to play an important role in wound healing. In this study wound fluid collected from patients after radical mastectomy was analyzed for PDGF-related factors. Analysis revealed the presence of two PDGF-related peptides of 16-17 kDa and 34-36 kDa. These PDGF-related peptides were purified by using anti-PDGF immunoaffinity techniques and found to possess both chemotactic and mitogenic activities for NIH 3T3 cells in vitro. Surprisingly, we could not detect authentic native PDGF (30 kDa) or PDGF A or B chain in any of the wound-fluid samples examined. These results indicate that PDGF-related peptides are present in normal human wound fluid, whereas PDGF A- and B-chain peptides are absent or only present in trace amounts relative to the total PDGF-related biological activity.

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References

    1. J Biophys Biochem Cytol. 1961 Dec;11:677-700 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3669-72 - PubMed
    1. J Cell Biol. 1982 Feb;92(2):584-8 - PubMed
    1. J Cell Physiol. 1988 Mar;134(3):437-44 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Aug;75(8):4001-5 - PubMed

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