Cereblon in health and disease

Hyoung Kyu Kim^{1

2}, Tae Hee Ko¹, Bayalagmaa Nyamaa¹, Sung Ryul Lee^{1

2}, Nari Kim¹, Kyung Soo Ko¹, Byoung Doo Rhee¹, Chul-Seung Park³, Bernd Nilius⁴, Jin Han⁵

Affiliations

¹ National Research Laboratory for Mitochondrial Signaling, Department of Physiology, Department of Health Sciences and Technology, BK21 plus Project Team, Cardiovascular and Metabolic Disease Center, College of Medicine, Inje University, Bokji-ro 75, Busanjin-gu, Busan, 47392, South Korea.
² Department of Integrated Biomedical Science, College of Medicine, Inje University, Busan, South Korea.
³ School of Life Sciences and National Leading Research Laboratory for Ion Channels, Gwangju Institute Science and Technology, Gwangju, 500-712, South Korea.
⁴ Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
⁵ National Research Laboratory for Mitochondrial Signaling, Department of Physiology, Department of Health Sciences and Technology, BK21 plus Project Team, Cardiovascular and Metabolic Disease Center, College of Medicine, Inje University, Bokji-ro 75, Busanjin-gu, Busan, 47392, South Korea. phyhanj@inje.ac.kr.

PMID: 27343012
DOI: 10.1007/s00424-016-1854-1

Review

Cereblon in health and disease

Hyoung Kyu Kim et al. Pflugers Arch. 2016 Aug.

. 2016 Aug;468(8):1299-309.

doi: 10.1007/s00424-016-1854-1. Epub 2016 Jun 24.

Authors

Hyoung Kyu Kim^{1

2}, Tae Hee Ko¹, Bayalagmaa Nyamaa¹, Sung Ryul Lee^{1

2}, Nari Kim¹, Kyung Soo Ko¹, Byoung Doo Rhee¹, Chul-Seung Park³, Bernd Nilius⁴, Jin Han⁵

Affiliations

¹ National Research Laboratory for Mitochondrial Signaling, Department of Physiology, Department of Health Sciences and Technology, BK21 plus Project Team, Cardiovascular and Metabolic Disease Center, College of Medicine, Inje University, Bokji-ro 75, Busanjin-gu, Busan, 47392, South Korea.
² Department of Integrated Biomedical Science, College of Medicine, Inje University, Busan, South Korea.
³ School of Life Sciences and National Leading Research Laboratory for Ion Channels, Gwangju Institute Science and Technology, Gwangju, 500-712, South Korea.
⁴ Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
⁵ National Research Laboratory for Mitochondrial Signaling, Department of Physiology, Department of Health Sciences and Technology, BK21 plus Project Team, Cardiovascular and Metabolic Disease Center, College of Medicine, Inje University, Bokji-ro 75, Busanjin-gu, Busan, 47392, South Korea. phyhanj@inje.ac.kr.

PMID: 27343012
DOI: 10.1007/s00424-016-1854-1

Abstract

Cereblon (CRBN) is a substrate receptor of the E3 ubiquitin ligase complex that has been linked to autosomal recessive non-syndromic mental retardation. Several key findings suggest diverse roles of CRBN, including its regulation of the large-conductance calcium- and voltage-activated potassium (BKCa) channels, regulation of thalidomide-binding proteins, and mediation of lenalidomide treatment in multiple myeloma. Recent studies also indicate that CRBN is involved in energy metabolism and negatively regulates AMP-activated protein kinase signaling. Mice with genetic depletion of CRBN are resistant to various stress conditions including a high-fat diet, endoplasmic reticulum stress, ischemia/reperfusion injury, and alcohol-related liver damage. In this review, we discuss the various roles of CRBN in human health and disease and suggest avenues for further research to enhance our basic knowledge and clinical application of CRBN.

Keywords: AMPK; BKCa; Cereblon; E3 ligase complex; Immunomodulatory drugs; Mental retardation.

PubMed Disclaimer

References

1. Lancet. 1981 Jun 27;1(8235):1427-8 - PubMed
1. Sci Rep. 2015 May 29;5:10667 - PubMed
1. Br J Haematol. 2013 Jun;161(5):695-700 - PubMed
1. Neurology. 2004 Nov 23;63(10):1927-31 - PubMed
1. Neurogenetics. 2008 Jul;9(3):219-23 - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Springer
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Cereblon in health and disease

Affiliations

Cereblon in health and disease

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources