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Review
. 2016:903:17-28.
doi: 10.1007/978-1-4899-7678-9_2.

Developmental Origins of Hypoxic Pulmonary Hypertension and Systemic Vascular Dysfunction: Evidence from Humans

Claudio Sartori  1 , Stefano F Rimoldi  2 , Hervé Duplain  3 , Thomas Stuber  4 , Sophie Garcin  3 , Emrush Rexhaj  2 , Yves Allemann  2 , Urs Scherrer  2   5
Affiliations
Review

Developmental Origins of Hypoxic Pulmonary Hypertension and Systemic Vascular Dysfunction: Evidence from Humans

Claudio Sartori et al. Adv Exp Med Biol. 2016.

Abstract

Epidemiological studies have shown an association between pathologic events occurring during fetal/perinatal life and the development of cardiovascular and metabolic disease in adulthood. These observations have led to the so-called developmental origin of adult disease hypothesis. More recently, evidence has been provided that the pulmonary circulation is also an important target for the developmental programming of adult disease in both experimental animal models and in humans. Here we will review this evidence and provide insight into mechanisms that may play a pathogenic role.

Keywords: Barker hypothesis; Epigenetics; Perinatal insult.

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