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Editorial
. 2016 Jul 19;7(29):44871-44872.
doi: 10.18632/oncotarget.10168.

TNF-driven cell fate: till HACE do us part

Luigi Tortola  1 , Roberto Nitsch  1 , Josef M Penninger  1
Affiliations
Editorial

TNF-driven cell fate: till HACE do us part

Luigi Tortola et al. Oncotarget. .
No abstract available

Keywords: HACE1; NFkB; TNF; apoptosis; necroptosis.

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Figures

Figure 1
Figure 1. HACE1 controls cell fate in response to TNFR1 ligation
Upon stimulation with TNF, HACE1 mediates the induction of NFκB activation and apoptosis, thereby maintaining a balance among the possible cell fates downstream of TNFR1 (left panel). In the absence of HACE1, NFκB activation and apoptosis induction downstream of TNFR1 are impaired and cells are predisposed to necroptotic death, which promotes intestinal inflammation and carcinogenesis (right panel).
See this image and copyright information in PMC

Comment on

  • The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.
    Tortola L, Nitsch R, Bertrand MJM, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, Hanada T, Takahashi N, Kernbauer E, Demiröz D, Lang M, Superti-Furga G, Decker T, Pichler A, Ikeda F, Kroemer G, Vandenabeele P, Sorensen PH, Penninger JM. Tortola L, et al. Cell Rep. 2016 May 17;15(7):1481-1492. doi: 10.1016/j.celrep.2016.04.032. Epub 2016 May 5. Cell Rep. 2016. PMID: 27160902 Free PMC article.

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