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. 2016 Sep 6;49(13):2726-2733.
doi: 10.1016/j.jbiomech.2016.06.002. Epub 2016 Jun 8.

3D MRI-based multicomponent thin layer structure only plaque models for atherosclerotic plaques

Xueying Huang  1 , Chun Yang  2 , Jie Zheng  3 , Richard Bach  4 , David Muccigrosso  3 , Pamela K Woodard  3 , Dalin Tang  5
Affiliations

3D MRI-based multicomponent thin layer structure only plaque models for atherosclerotic plaques

Xueying Huang et al. J Biomech. .

Abstract

MRI-based fluid-structure interactions (FSI) models for atherosclerotic plaques have been developed to perform mechanical analysis to investigate the association of plaque wall stress (PWS) with cardiovascular disease. However, the time consuming 3D FSI model construction process is a great hinder for its clinical implementations. In this study, a 3D thin-layer structure only (TLS) plaque model was proposed as an approximation with much less computational cost to 3D FSI models for better clinical implementation potential. 192 TLS models were constructed based on 192 ex vivo MRI Images of 12 human coronary atherosclerotic plaques. Plaque stresses were extracted from all lumen nodal points. The maximum value of Plaque wall stress (MPWS) and average value of plaque wall stress (APWS) of each slice were used to compare with those from corresponding FSI models. The relative errors for MPWS and APWS were 9.76% and 9.89%, respectively. Both MPWS and APWS values obtained from TLS models showed very good correlation with those from 3D FSI models. Correlation results from TLS models were in consistent with FSI models. Our results indicated that the proposed 3D TLS plaque models may be used as a good approximation to 3D FSI models with much less computational cost. With further validation, 3D TLS models may be possibly used to replace FSI models to save time and perform mechanical analysis for atherosclerotic plaques for clinical implementation.

Keywords: Fluid-structure interactions; Stress; Thin layer structure only model; Vulnerable atherosclerotic plaques.

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Conflict of interest statement

statement We confirm that all authors of this manuscript have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
T1 and T2-weighted MR images of a human coronary plaque sample with lipid validated by histology.
Figure 2
Figure 2
A typical cardiac pressure profile scaled with patient-specific systolic (93 mmHg) and diastolic (65 mmHg) pressure from the last hospital admission and used as upstream pressure condition (Pin) for the computational simulations of the plaque sample shown in Figure 1.
Figure 3
Figure 3
Band plots of PWS of slice on Figure 1 (d) showing the comparison of TLS and FSI models. a) Band plots of PWS for Slice 7 from TLS model; b) Band plot of PWS from FSI model; c) Comparison of pressurized contours between TLS and FSI model.
Figure 4
Figure 4
Stress Correlations. a) correlations between maximum PWS obtained by TLS and FSI models; b) correlations between average PWS obtained by TLS and FSI models.
Figure 5
Figure 5
Box plots show the comparisons of Maximum PWS values of each slice obtained from TLS and FSI models for each plaque.
Figure 6
Figure 6
Box plots show the comparisons of Average PWS values of each slice obtained from TLS and FSI models for each plaque
Figure 7
Figure 7
Comparison of correlation results of mean-quarter plaque wall stress vs. mean-quarter vessel wall thickness distribution plots from selected 3 patients between TLS and FSI models.
See this image and copyright information in PMC

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