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. 2016 Aug:61:82-85.
doi: 10.1016/j.yebeh.2016.05.004. Epub 2016 Jun 23.

Utilization of antiepileptic drugs in Israel

Erez Berman  1 , Eli Marom  2 , Dana Ekstein  3 , Ilan Blatt  4 , Sara Eyal  5
Affiliations

Utilization of antiepileptic drugs in Israel

Erez Berman et al. Epilepsy Behav. 2016 Aug.

Abstract

Purpose: The aim of the study was to identify trends in utilization of antiepileptic drugs (AEDs) over time in a nation-wide population in Israel.

Methods: Data on AED utilization (for all indications) for the period 2010-2014 were obtained from pharmaceutical companies that distribute AEDs in Israel. Prevalence of AED utilization was reported as defined daily doses (DDD)/1000 inhabitants/day.

Results: The utilization of most AEDs included in our analysis remained stable over the study period. The greatest increases in utilization of drugs established in Israel were observed for lamotrigine (33%), oxcarbazepine (31%), and primidone (18%). Decreases in use were recorded for carbamazepine (18%) and phenobarbital (15%). Use of older AEDs appeared to be relatively high, compared with the use of newer AEDs.

Conclusions: During the study period of 2010-2014, conventional AEDs remained a main treatment choice in Israel, in certain cases in contrast to current recommendations and guidelines, for reasons yet to be revealed in further research.

Keywords: Antiepileptic drugs; Drug preparations; Drug utilization.

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MeSH terms

Substances