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Review
. 2016 Oct;40(6):385-390.
doi: 10.1053/j.semperi.2016.05.009. Epub 2016 Jun 23.

Hypothermia for neonatal hypoxic-ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field

Seetha Shankaran  1 , Girija Natarajan  2 , Lina Chalak  3 , Athina Pappas  2 , Scott A McDonald  4 , Abbot R Laptook  5
Affiliations
Review

Hypothermia for neonatal hypoxic-ischemic encephalopathy: NICHD Neonatal Research Network contribution to the field

Seetha Shankaran et al. Semin Perinatol. 2016 Oct.

Abstract

In this article, we summarize the NICHD Neonatal Research Network (NRN) trial of whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy in relation to other randomized controlled trials (RCTs) of hypothermia neuroprotection. We describe the NRN secondary studies that have been published in the past 10 years evaluating clinical, genetic, biochemical, and imaging biomarkers of outcome.

Keywords: Biomarkers; Hypothermia Neuroprotection; Hypoxic-ischemic encephalopathy; Neonatal.

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References

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