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. 2016 Aug 1;8(8):734-8.
doi: 10.1039/c6mt00129g.

Association of B12 deficiency and anemia synergistically increases the risk of high TNF-α levels among adolescent girls

N S Ghatpande  1 , P P Apte  1 , S S Naik  2 , B N Joshi  1 , M K Gokhale  1 , P P Kulkarni  1
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Association of B12 deficiency and anemia synergistically increases the risk of high TNF-α levels among adolescent girls

N S Ghatpande et al. Metallomics. .

Abstract

We investigated the association between iron status, B12, and inflammatory markers among 101 adolescent girls. We found that B12 showed significant negative association with tumor necrosis factor-alpha (TNF-α) (rs = -0.232, P = 0.020) and positive association with serum ferritin (SF) (rs = 0.209, P = 0.036) among girls. Our results showed that hepcidin discriminates anemic and non-anemic population under normal B12 conditions. The logistic regression analysis revealed that the risk of having higher TNF-α levels was 13.2 times higher in low B12 girls in the presence of anemia compared to the girls having normal hemoglobin and B12 levels.

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