Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jun 27:6:28675.
doi: 10.1038/srep28675.

Risk of Band Keratopathy in Patients with End-Stage Renal Disease

Shih-Feng Weng  1 , Ren-Long Jan  2   3 , Chun Chang  4 , Jhi-Joung Wang  5   6 , Shih-Bin Su  7   8 , Chien-Cheng Huang  7   9 , Sung-Huei Tseng  10   11 , Yuh-Shin Chang  10   12
Affiliations

Risk of Band Keratopathy in Patients with End-Stage Renal Disease

Shih-Feng Weng et al. Sci Rep. .

Abstract

This study is a retrospective, nationwide, matched cohort study to investigate the risk of band keratopathy following end-stage renal disease (ESRD). The study cohort included 94,039 ESRD on-dialysis patients identified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM), code 585 and registered between January 2000 to December 2009 at the Taiwan National Health Insurance Research Database. An age- and sex-matched control group comprised 94,039 patients selected from the Taiwan Longitudinal Health Insurance Database 2000. Information for each patient was collected from the index date until December 2011. In total, 230 ESRD patients and 26 controls had band keratopathy (P < 0.0001) during the follow-up period, indicating a significantly elevated risk of band keratopathy in the ESRD patients compared with controls (incidence rate ratio = 12.21, 95% confidence interval [CI] = 8.14-18.32). After adjustment for potential confounders including sarcoidosis, hyperparathyroidism, iridocyclitis, and phthisis bulbi, ESRD patients were 11.56 times more likely to develop band keratopathy in the full cohort (adjusted HR = 11.56, 95% CI = 7.70-17.35). In conclusion, ESRD increases the risk of band keratopathy. Close interdisciplinary collaboration between nephrologists and ophthalmologists is important to deal with band keratopathy following ESRD and prevent visual acuity impairments.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Kaplan–Meier curve of cumulative incidence of band keratopathy in patients with end-stage renal disease (ESRD) and controls during the follow-up period.
See this image and copyright information in PMC

References

    1. Levey A. S. et al.. Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes. Kidney international 72, 247–259 (2007). - PubMed
    1. Meguid El Nahas A. & Bello A. K. Chronic kidney disease: the global challenge. Lancet 365, 331–340 (2005). - PubMed
    1. Hwang S. J., Tsai J. C. & Chen H. C. Epidemiology, impact and preventive care of chronic kidney disease in Taiwan. Nephrology (Carlton) 15 Suppl 2, 3–9 (2010). - PubMed
    1. Coresh J. et al.. Prevalence of chronic kidney disease in the United States. Jama 298, 2038–2047 (2007). - PubMed
    1. McClellan W. et al.. Racial differences in the prevalence of chronic kidney disease among participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort Study. Journal of the American Society of Nephrology : JASN 17, 1710–1715 (2006). - PubMed

Supplementary concepts