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. 2016 Aug;47(3):220-6.
doi: 10.1093/labmed/lmw021. Epub 2016 Jun 26.

Laboratory Diagnosis of Factor XIII Deficiency in Developing Countries: An Iranian Experience

Akbar Dorgalaleh  1 , Shadi Tabibian  2 , Mahmood Shams  3 , Behnaz Tavasoli  2 , Maryam Gheidishahran  2 , Morteza Shamsizadeh  4
Affiliations

Laboratory Diagnosis of Factor XIII Deficiency in Developing Countries: An Iranian Experience

Akbar Dorgalaleh et al. Lab Med. 2016 Aug.

Abstract

Factor XIII (FXIII) deficiency is an extremely rare bleeding disorder with an approximately 12-times higher than the rest of the world. The International Society for Thrombosis and Hemostasis (ISTH) suggested a standard algorithm for precise diagnosis and classification of FXIII deficiency (FXIIID). However, due to lack of investment in proper equipment and procedures in Iran, almost no part of this algorithm can be used to diagnose Iranian patients. Thus, this study proposes a guideline for accurate molecular and laboratory diagnosis of FXIIID based on the available tools. Because this study suggests a simple and reliable algorithm for early diagnosis, it can therefore, reduce the rates of morbidity and mortality of FXIIID patients with this condition.

Keywords: ISTH; Iran; developing countries; factor XIII deficiency; laboratory diagnosis; rare bleeding disorders.

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Figures

Figure 1
Figure 1
Suggested algorithm by International Society for Thrombosis and Hemostasis (ISTH) for proper diagnosis and classification of factor XIII deficiency. FXIII indicates Factor XIII; FXIIID, FXIII disorder.
Image 1
Image 1
Iranian provinces in which the greatest number of cases of Factor XIII deficiency are found.
Figure 2
Figure 2
Suggested algorithm for molecular diagnosis of factor XIII deficiency in Iran.
Figure 3
Figure 3
Suggested algorithm of diagnosis of factor XIII deficiency in Iran.
See this image and copyright information in PMC

References

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