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. 2016 Apr 29:12:24-37.
doi: 10.2174/1745017901612010024. eCollection 2016.

Dehydroepiandrosterone, Its Sulfate and Cognitive Functions

Karina Junqueira de Menezes  1 , Clayton Peixoto  1 , Antonio Egidio Nardi  1 , Mauro Giovanni Carta  2 , Sérgio Machado  1 , André Barciela Veras  3
Affiliations

Dehydroepiandrosterone, Its Sulfate and Cognitive Functions

Karina Junqueira de Menezes et al. Clin Pract Epidemiol Ment Health. .

Abstract

To present a review of cross-sectional and longitudinal studies that investigate the relationship between the hormones Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone sulfate (DHEA-S) and cognition.

Methods: The cognition items included in this review were global cognitive function, memory, attention, executive function, intelligence, perception and visuospatial ability. A systematic review was proceeded using three databases: PubMed, ISI Web of Science, and PsycINFO.

Results: Two thousand fifty five references about cognition and hormones were found; 772 duplicated references were excluded, resulting in 1.283 references to be evaluated. According to exclusion and inclusion criteria, 25 references were selected. A positive correlation between DHEA-S blood levels and global cognition was found in women and men. Other positive correlations between DHEA-S and working memory, attention and verbal fluency were found only in women. The DHEA effect on cognition is limited to one study conducted among young men with high-doses.

Keywords: Attention; Cognition; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Executive Function; Memory; Neuropsychology.

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Figures

Fig. (1)
Fig. (1)
Flowchart of the different phases of the systematic review.
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