Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jun 24;17(7):1007.
doi: 10.3390/ijms17071007.

PBK/TOPK Expression Predicts Prognosis in Oral Cancer

Chin-Fang Chang  1   2 , Sung-Lang Chen  3   4 , Wen-Wei Sung  5   6   7   8 , Ming-Ju Hsieh  9   10   11 , Hui-Ting Hsu  12   13   14 , Li-Hsin Chen  15 , Mu-Kuan Chen  16   17 , Jiunn-Liang Ko  18 , Chih-Jung Chen  19   20   21 , Ming-Chih Chou  22   23
Affiliations

PBK/TOPK Expression Predicts Prognosis in Oral Cancer

Chin-Fang Chang et al. Int J Mol Sci. .

Abstract

Oral cancer is a common cancer with poor prognosis. We evaluated the expression of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) and its prognostic significance in oral cancer. PBK/TOPK expression was measured by immunohistochemical staining of samples from 287 patients with oral cancer. The association between PBK/TOPK expression and clinicopathological features was analyzed. The prognostic value of PBK/TOPK for overall survival was determined by Kaplan-Meier analysis and Cox proportional hazard models. A high PBK/TOPK expression level was correlated with long overall survival. The prognostic role of PBK/TOPK expression was significant in young patients (p < 0.05), patients with smoking habits (p < 0.05), and late stage disease (p < 0.05). Our results suggest that PBK/TOPK expression is enhanced in oral cancer. High PBK/TOPK expression, either alone or in subgroups according to clinicopathological features, may serve as a favorable prognostic marker for patients with oral cancer.

Keywords: PBK (PDZ-binding kinase); TOPK (T-LAK cell-originated protein kinase); head and neck cancer; metastasis; oral squamous cell carcinoma; prognosis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Representative immunostaining of PBK/TOPK in tissue arrays from patients with oral squamous cell carcinoma. PBK/TOPK expression scores were (A) 0 (stage 1); (B) 100 (stage 4); (C) >200 (stage 1), Scale bar = 100× (200 μm).
Figure 2
Figure 2
Kaplan-Meier analysis of PBK/TOPK expression with respect to the overall survival of (A) all patients and; (B) patients with smoking habits.
See this image and copyright information in PMC

References

    1. Joshi P., Dutta S., Chaturvedi P., Nair S. Head and neck cancers in developing countries. Rambam Maimonides Med. J. 2014;5:e0009. doi: 10.5041/RMMJ.10143. - DOI - PMC - PubMed
    1. Lian I.B., Tseng Y.T., Su C.C., Tsai K.Y. Progression of precancerous lesions to oral cancer: Results based on the Taiwan National Health Insurance Database. Oral Oncol. 2013;49:427–430. doi: 10.1016/j.oraloncology.2012.12.004. - DOI - PubMed
    1. Ernani V., Saba N.F. Oral Cavity Cancer: Risk Factors, Pathology, and Management. Oncology. 2015;89:187–195. doi: 10.1159/000398801. - DOI - PubMed
    1. Choudhari S.K., Chaudhary M., Gadbail A.R., Sharma A., Tekade S. Oxidative and antioxidative mechanisms in oral cancer and precancer: A review. Oral Oncol. 2014;50:10–18. doi: 10.1016/j.oraloncology.2013.09.011. - DOI - PubMed
    1. Vairaktaris E., Serefoglou Z., Avgoustidis D., Yapijakis C., Critselis E., Vylliotis A., Spyridonidou S., Derka S., Vassiliou S., Nkenke E., et al. Gene polymorphisms related to angiogenesis, inflammation and thrombosis that influence risk for oral cancer. Oral Oncol. 2009;45:247–253. doi: 10.1016/j.oraloncology.2008.05.003. - DOI - PubMed

Substances

LinkOut - more resources