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Meta-Analysis
. 2016 Jun 28:6:28712.
doi: 10.1038/srep28712.

Changes in cerebral metabolites in obstructive sleep apnea: a systemic review and meta-analysis

Yunyan Xia  1   2   3 , Yiqun Fu  1   2   3 , Huajun Xu  1   2   3 , Jian Guan  1   2   3 , Hongliang Yi  1   2   3 , Shankai Yin  1   2   3
Affiliations
Meta-Analysis

Changes in cerebral metabolites in obstructive sleep apnea: a systemic review and meta-analysis

Yunyan Xia et al. Sci Rep. .

Abstract

Cognitive impairment is associated with changes in cerebral metabolites in patients with obstructive sleep apnea (OSA). Several studies have used magnetic resonance spectroscopy (MRS) to detect variations in cerebral metabolites; however, the results have been inconsistent. This meta-analysis summarizes the differences in cerebral metabolites between patients with OSA and controls. Two electronic databases, PubMed and Embase, were searched for articles (published before March 31, 2016) describing studies that used MRS to evaluate the cerebral metabolite changes. The overall effects were measured using the weighted mean difference with a 95% confidence interval. Subgroup analysis and sensitivity analysis were used to explore the sources of between-study heterogeneity and the stability of the results. Publication bias was also evaluated. Thirteen studies were ultimately included. In the hippocampus, the N-acetylaspartate (NAA)/creatine ratio was lower in patients with OSA. In the frontal lobe, only the NAA/choline ratio was lower in patients with OSA. Cerebral metabolites are significantly altered in the hippocampus in patients with OSA. Further clinical studies are needed to explore the underlying mechanisms between OSA and the changes in cerebral metabolites in the brain.

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Figures

Figure 1
Figure 1. Flow diagram of selection procedure in this meta-analysis showing the number of records retrieved and the number of studies included.
Figure 2
Figure 2. Neuropsychological deficits and cerebral metabolite changes in respective regions in OSA.
Abbreviation: OSA, obstructive sleep apnea; NAA, N-acetylaspartate; Cho, choline; Cr, creatine; mI, myo-inosito.
See this image and copyright information in PMC

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