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. 2016 Jun 28;18(7):722-4.
doi: 10.1038/ncb3382.

p21 shapes cancer evolution

Vasily S Romanov  1 , K Lenhard Rudolph  1
Affiliations

p21 shapes cancer evolution

Vasily S Romanov et al. Nat Cell Biol. .

Abstract

Although known to induce cellular senescence, an important tumour suppressor mechanism, mutation of CDKN1A - the gene encoding p21 (also known as WAF1 or CIP1) - is rare in human cancers. Now, a study reports a previously unappreciated oncogenic effect of p21 overexpression that shapes cancer genome evolution through induction of replication stress.

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References

    1. Science. 2015 May 22;348(6237):880-6 - PubMed
    1. Biochemistry (Mosc). 2012 Jun;77(6):575-84 - PubMed
    1. Nature. 2013 Feb 28;494(7438):492-6 - PubMed
    1. Arch Toxicol. 2015 Feb;89(2):155-78 - PubMed
    1. Mol Pharmacol. 2001 May;59(5):1119-28 - PubMed

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