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Review
. 2016 Nov;37(11):1765-1771.
doi: 10.1007/s10072-016-2643-5. Epub 2016 Jun 27.

The interplay of microRNAs and post-ischemic glutamate excitotoxicity: an emergent research field in stroke medicine

Alireza Majdi  1 , Javad Mahmoudi  2 , Saeed Sadigh-Eteghad  1 , Mehdi Farhoudi  1 , Siamak Sandoghchian Shotorbani  3
Affiliations
Review

The interplay of microRNAs and post-ischemic glutamate excitotoxicity: an emergent research field in stroke medicine

Alireza Majdi et al. Neurol Sci. 2016 Nov.

Abstract

Stroke is the second leading cause of death and the most common cause of adult disabilities among elderlies. It involves a complex series of mechanisms among which, excitotoxicity is of great importance. Also, miRNAs appear to play role in post-stroke excitotoxicity, and changes in their transcriptome occur right after cerebral ischemia. Recent data indicate that specific miRNAs such as miRNA-223, miRNA-181, miRNA-125a, miRNA-125b, miRNA-1000, miRNA-132 and miRNA-124a regulate glutamate neurotransmission and excitotoxicity during stroke. However, limitations such as poor in vivo stability, side effects and inappropriate biodistribution in miRNA-based therapies still exist and should be overcome before clinical application. Thence, investigation of the effect of application of these miRNAs after the onset of ischemia is a pivotal step for manipulating these miRNAs in clinical use. Given this, present review concentrates on miRNAs roles in post-ischemic stroke excitotoxicity.

Keywords: AMPA receptors; Glutamate excitotoxicity; Ischemic stroke; MicroRNA; NMDA receptors.

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References

    1. Glia. 2013 Jul;61(7):1018-28 - PubMed
    1. Neurochem Res. 2015 Feb;40(2):301-7 - PubMed
    1. BMC Neurol. 2014 Apr 08;14:77 - PubMed
    1. Oxid Med Cell Longev. 2015;2015:964518 - PubMed
    1. Brain Pathol. 2008 Jan;18(1):130-8 - PubMed

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