Weighing Evidence from Mendelian Randomization-Early-Life Obesity as a Causal Factor in Multiple Sclerosis?
- PMID: 27351631
- PMCID: PMC4924836
- DOI: 10.1371/journal.pmed.1002054
Weighing Evidence from Mendelian Randomization-Early-Life Obesity as a Causal Factor in Multiple Sclerosis?
Abstract
In this Perspective, Alberto Ascherio and Kassandra Munger discuss the implications of Richards and colleagues' study exploring the role of early-life obesity in risk of multiple sclerosis.
Conflict of interest statement
The authors have declared that no competing interests exist.
Comment on
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Obesity and Multiple Sclerosis: A Mendelian Randomization Study.PLoS Med. 2016 Jun 28;13(6):e1002053. doi: 10.1371/journal.pmed.1002053. eCollection 2016 Jun. PLoS Med. 2016. PMID: 27351487 Free PMC article.
References
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- Gianfrancesco MA, Acuna B, Shen L, Briggs FB, Quach H, et al. (2014) Obesity during childhood and adolescence increases susceptibility to multiple sclerosis after accounting for established genetic and environmental risk factors. Obes Res Clin Pract 8: e435–447. 10.1016/j.orcp.2014.01.002 - DOI - PMC - PubMed
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