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. 2016 Dec;27(12):3525-3533.
doi: 10.1007/s00198-016-3682-8. Epub 2016 Jun 28.

Visceral fat measured by DXA is associated with increased risk of non-spine fractures in nonobese elderly women: a population-based prospective cohort analysis from the São Paulo Ageing & Health (SPAH) Study

L G Machado  1 , D S Domiciano  1 , C P Figueiredo  1 , V F Caparbo  1 , L Takayama  1 , R M Oliveira  2 , J B Lopes  1 , P R Menezes  3 , R M R Pereira  4
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Visceral fat measured by DXA is associated with increased risk of non-spine fractures in nonobese elderly women: a population-based prospective cohort analysis from the São Paulo Ageing & Health (SPAH) Study

L G Machado et al. Osteoporos Int. 2016 Dec.

Abstract

The present study investigates the relationship between visceral fat measured by dual-energy X-ray absorptiometry (DXA) and the incidence of non-spine fractures in community-dwelling elderly women. We demonstrated a potential negative effect of visceral fat on bone health in nonobese women.

Introduction: The protective effect of obesity on bone health has been questioned because visceral fat has been demonstrated to have a deleterious effect on bone. The aim of this study was to investigate the association of visceral fat measured by DXA with the incidence of non-spine fractures in community-dwelling elderly women.

Methods: This longitudinal prospective population-based cohort study evaluated 433 community-dwelling women aged 65 years or older. A specific clinical questionnaire, including personal history of a fragility fracture in non-spine osteoporotic sites, was administered at baseline and after an average of 4.3 years. All incidences of fragility fractures during the study period were confirmed by affected-site radiography. Visceral adipose tissue (VAT) was measured in the android region of a whole-body DXA scan.

Results: The mean age was 72.8 ± 4.7 years, and 28 incident non-spine osteoporotic fractures were identified after a mean follow-up time of 4.3 ± 0.8 years. According to the Lipschitz classification for nutritional status in the elderly, 38.6 % of women were nonobese (BMI ≤ 27 kg/m2) and 61.4 % were obese/overweight. Logistic regression models were used to estimate the relationship between VAT and non-spine fractures in elderly women. After adjusting for age, race, previous fractures, and BMD, VAT (mass, area, volume) had a significant association with the incidence of non-spine fractures only in nonobese elderly women (VAT mass: OR, 1.42 [95 % CI, 1.09-1.85; p = 0.010]; VAT area: OR, 1.19 [95 % CI, 1.05-1.36; p = 0.008]; VAT volume: OR, 1.40 [95 % CI, 1.09-1.80; p = 0.009]).

Conclusion: This study suggests a potential negative effect of visceral adiposity on bone health in nonobese women.

Keywords: Bone–fat interactions; DXA; Elderly; Non-spine fractures; Visceral fat.

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References

    1. Curr Osteoporos Rep. 2011 Jun;9(2):67-75 - PubMed
    1. Osteoporos Int. 2013 Feb;24(2):595-603 - PubMed
    1. Maturitas. 2011 May;69(1):86-90 - PubMed
    1. Obesity (Silver Spring). 2012 Jun;20(6):1313-8 - PubMed
    1. Am J Med. 2011 Nov;124(11):1043-50 - PubMed

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