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Review
. 2016 Sep;13(9):756-9.
doi: 10.1080/15476286.2016.1201628. Epub 2016 Jun 28.

m(6)A: Signaling for mRNA splicing

Samir Adhikari  1 , Wen Xiao  1 , Yong-Liang Zhao  2 , Yun-Gui Yang  1
Affiliations
Review

m(6)A: Signaling for mRNA splicing

Samir Adhikari et al. RNA Biol. 2016 Sep.

Abstract

Among myriads of distinct chemical modifications in RNAs, dynamic N6-methyladenosine (m(6)A) is one of the most prevalent modifications in eukaryotic mRNAs and non-coding RNAs. Similar to the critical role of chemical modifications in regulation of DNA and protein activities, RNA m(6)A modification is also observed to be involved in the regulation of diverse functions of RNAs including meiosis, fertility, development, cell reprogramming and circadian period. The RNA m(6)A modification is recognized by YTH domain containing family proteins comprising of YTHDC1-2 and YTHDF1-3. Here we focus on the nuclear m(6)A reader YTHDC1 and its regulatory role in alternative splicing and other RNA metabolic processes.

Keywords: Alternative splicing; SRSF10; SRSF3; YTHDC1; m6A.

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