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Review
. 2016 Dec:46:286-291.
doi: 10.1016/j.meegid.2016.06.047. Epub 2016 Jun 25.

Differences among HIV-1 subtypes in drug resistance against integrase inhibitors

Ying-Shan Han  1 , Thibault Mesplède  1 , Mark A Wainberg  2
Affiliations
Review

Differences among HIV-1 subtypes in drug resistance against integrase inhibitors

Ying-Shan Han et al. Infect Genet Evol. 2016 Dec.

Abstract

Three integrase strand transfer inhibitors (INSTIs), raltegravir (RAL), elvitegravir (EVG) and dolutegravir (DTG), have been approved by the FDA. Resistance against these three INSTIs have been reported and cross-resistance among them has been documented. Due to extensive and dynamic genetic diversity in different HIV-1 variants, significant differences in susceptibility to the INSTIs have been observed among HIV subtypes. This review summarizes what is known about this topic and discusses possible clinical implications.

Keywords: Drug resistance; HIV subtypes; Integrase inhibitors.

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