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Comment
. 2016 Jun 29;20(1):189.
doi: 10.1186/s13054-016-1345-y.

Surrogate endpoints and competing risk of death in cardiac arrest research

Victoria A McCredie  1   2   3 , Damon C Scales  4   5   6
Affiliations
Comment

Surrogate endpoints and competing risk of death in cardiac arrest research

Victoria A McCredie et al. Crit Care. .

Abstract

We urgently need new therapies to improve outcomes after cardiac arrest. Initial studies typically target surrogate endpoints, and these studies help to inform subsequent larger trials that are powered to measure more patient-orientated clinical outcomes such as survival. The competing risk of death and premature assessment of neurological prognosis pose significant challenges to measuring these surrogate endpoints after cardiac arrest.

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References

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