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Review
. 2016 Jun 26;8(6):362-7.
doi: 10.4330/wjc.v8.i6.362.

Thrombosis in ST-elevation myocardial infarction: Insights from thrombi retrieved by aspiration thrombectomy

Daniel Rios P Ribeiro  1 , Eduardo Cambruzzi  1 , Marcia Moura Schmidt  1 , Alexandre S Quadros  1
Affiliations
Review

Thrombosis in ST-elevation myocardial infarction: Insights from thrombi retrieved by aspiration thrombectomy

Daniel Rios P Ribeiro et al. World J Cardiol. .

Abstract

In patients with ST-elevation myocardial infarction, recurrent cardiovascular events still remain the main cause of morbidity and mortality, despite significant improvements in antithrombotic therapy. We sought to review data regarding coronary thrombus analysis provided by studies using manual aspiration thrombectomy (AT), and to discuss how insights from this line of investigation could further improve management of acute coronary disease. Several studies investigated the fresh specimens retrieved by AT using techniques such as traditional morphological evaluation, optical microscopy, scanning electron microscopy, magnetic resonance imaging, and immunohistochemistry. These approaches have provided a better understanding of the composition and dynamics of the human coronary thrombosis process, as well as its relationship with some clinical outcomes. Recent data signaling to new antithrombotic therapeutic targets are still emerging.

Keywords: Aspiration; Immunohistocytochemistry; Mechanical; Myocardial infarct; Thrombectomy; Thrombus.

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Figures

Figure 1
Figure 1
Recent coronary thrombus composed of fibrin, white blood cells and red blood cells, hematoxylin-eosin, 200 ×.
Figure 2
Figure 2
Coronary thrombus with lysis focuses in few neutrophils, hematoxylin-eosin, 200 ×.
See this image and copyright information in PMC

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