A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions

Abstract

Transient global amnesia is a clinical syndrome characterized by the sudden onset of anterograde amnesia, accompanied by repetitive questioning, sometimes with a retrograde component, lasting up to 24 hours, without compromise of other neurologic function. Neuroimaging after an acutetransient global amnesia event often shows transient perturbation of specific hippocampal circuits that are involved in memory processing. Critical clinical distinctions, such as between transient global amnesia and other forms of transient amnesic episodes, as well as important clues to the underlying pathophysiologies are herein reviewed. Finally, we discuss the role of hippocampal insufficiency in the neurobiology of delusions.

Keywords: Transient global amnesia; delusions; hippocampus; neurobiology.

FIGURE 1.

Neural circuitry and signaling in non-paranoid state,,

FIGURE 2.

Proposed neural circuitry and signaling in paranoid delusions,-