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Review
. 2016 Jun 27:11:4.
doi: 10.1186/s13013-016-0066-y. eCollection 2016.

Adolescent idiopathic scoliosis: current concepts on neurological and muscular etiologies

Marcelo Wajchenberg  1 , Nelson Astur  2 , Michel Kanas  1 , Délio Eulálio Martins  1
Affiliations
Review

Adolescent idiopathic scoliosis: current concepts on neurological and muscular etiologies

Marcelo Wajchenberg et al. Scoliosis Spinal Disord. .

Abstract

Adolescent idiopathic scoliosis (AIS) is a frequent disease but its etiology remains unknown. Gender prevalence in females is already known and there are many suggested hypotheses to explain its origin and manifestation, like associated neurologic, muscular and connective tissue disorders. Literature reports have tried to analyze disease prevalence in selected populations, possible ways of inheritance, related genes location and their polymorphisms, which may play a role in the development of the deformity. The purpose of this paper is to review and update concepts on the origin and genetic influence on AIS.

Keywords: Adolescent; Genetics; Scoliosis/etiology.

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References

    1. Ocaka L, Zhao C, Reed JA, Ebenezer ND, Brice G, Morley T, et al. Assignment of two loci for autosomal dominant adolescent idiopathic scoliosis to chromosomes 9q31.2-q34.2 and 17q25.3-qtel. J Med Genet. 2008;45(2):87–92. doi: 10.1136/jmg.2007.051896. - DOI - PubMed
    1. Cobb JR. Outline for the study of scoliosis. American Academy of Orthopaedic Surgeons Instructional Course Lectures. 1948;5:261–5.
    1. Wynne-Davies R. Familial (idiopathic) scoliosis. A family survey. J Bone Joint Surg (Br) 1968;50(1):24–30. - PubMed
    1. Lonstein JE. Adolescent idiopathic scoliosis. Lancet. 1994;344(8934):1407–12. doi: 10.1016/S0140-6736(94)90572-X. - DOI - PubMed
    1. Galton F. The history of twins as a criterion of the relative posers of a nature and nuture. Pop Sci Monthly. 1875;8:345.

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