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Editorial
. 2016 Aug;34(8):1500-1.
doi: 10.1097/HJH.0000000000001031.

Amiloride and the diabetic kidney

Mark C Chappell  1
Affiliations
Editorial

Amiloride and the diabetic kidney

Mark C Chappell. J Hypertens. 2016 Aug.
No abstract available

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Conflict of interest statement

Conflicts of interest

There are no conflicts of interest.

Comment on

References

    1. Andersen H, Hansen PBL, Bistrup C, Nielsen F, Henriksen JE, Jensen BL. Significant natriuretic and antihypertensive action of the epithelial sodium channel blocker amiloride in diabetic patients with and without nephropathy. J Hypertens 2016; 34:1621–1629. - PubMed
    1. Andersen H, Friis UG, Hansen PB, Svenningsen P, Henriksen JE, Jensen BL. Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells. Nephrol Dial Transplant 2015; 30:781–789. - PubMed
    1. Andersen RF, Buhl KB, Jensen BL, Svenningsen P, Friis UG, Jespersen B, et al. Remission of nephrotic syndrome diminishes urinary plasmin content and abolishes activation of ENaC. Pediatr Nephrol 2013; 28:1227–1234. - PubMed
    1. Buhl KB, Oxlund CS, Friis UG, Svenningsen P, Bistrup C, Jacobsen IA, et al. Plasmin in urine from patients with type 2 diabetes and treatment-resistant hypertension activates ENaC in vitro. J Hypertens 2014; 32:1672–1677. - PubMed
    1. Staehr M, Buhl KB, Andersen RF, Svenningsen P, Nielsen F, Hinrichs GR, et al. Aberrant glomerular filtration of urokinase-type plasminogen activator in nephrotic syndrome leads to amiloride-sensitive plasminogen activation in urine. Am J Physiol Renal Physiol 2015; 309:F235–F241. - PubMed