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Comment
. 2014 Apr 2:1:8.
doi: 10.3978/j.issn.2306-9759.2014.03.05. eCollection 2014.

Megakaryocytes regulate the quiescence of hematopoietic stem cells through PF4: 2013 ASH meeting highlights

Yamei Chen  1 , Delong Liu  1
Affiliations
Comment

Megakaryocytes regulate the quiescence of hematopoietic stem cells through PF4: 2013 ASH meeting highlights

Yamei Chen et al. Stem Cell Investig. .

Abstract

Hematopoietic stem cells (HSCs) can take one of the three different pathways: quiescence, self-renewal and differentiation. Mechanisms that control the tight balance to maintain lifelong hematopoietic homeostasis have been a major interest of research. Platelet factor-4 (PF4), a weak chemokine, is synthesized exclusively by megakaryocytes and sequestered in platelets. This meeting report highlights a novel study presented at 2013 ASH annual meeting. This study found that megakaryocyte, a progeny of HSC, was involved in maintaining quiescence of HSCs via PF4 in a feedback loop.

Keywords: Hematopoietic stem cell (HSC); megakaryocytes; platelet factor-4 (PF4).

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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